Giant negative T waves during interferon therapy in a patient with chronic hepatitis c

Takayuki Fujiwara, Katsuyuki Kiura, Koji Ochi, Hiromi Matsubara, Hiroshi Yamanari, Hiroyuki Shimomura, Mine Harada

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Interferon-α (IFN-α) has been widely used for treatment of chronic hepatitis C in Japan. In general, cardiovascular adverse reactions are rare in association with IFN-α therapy. Here, a 64-year-old man with chronic active hepatitis C complained of fatigue, palpitation and depression, and developed atrial fibrillation with prominent negative T waves during IFN-α therapy. Echocardiogram showed septal and apical hypertrophy. Three days after discontinuation of IFN-α, subjective symptoms and atrial fibrillation subsided. It is unclear whether or not IFN-α induced the giant negative T waves with apical hypertrophy. We might observe the developing course of hepatitis C virus (HCV) related myocardial hypertrophy by chance. Cardiovascular toxicity should be carefully monitored during IFN-α therapy even in patients with minor cardiac disease, such as premature ventricular contracture (PVC) and mild hypertension.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalInternal Medicine
Issue number2
Publication statusPublished - Feb 2001


  • Giant negative T waves
  • Hypertension
  • Interferon-α

ASJC Scopus subject areas

  • Internal Medicine


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