TY - GEN
T1 - GLASS MICROFLUIDIC PLATFORM FOR NANOWIRE-ASSISTED URINARY CELL-FREE DNA ISOLATION
AU - Takahashi, Hiromi
AU - Yasui, Takao
AU - Shinjo, Keiko
AU - Miyazaki, Yusuke
AU - Shinoda, Wataru
AU - Hasegawa, Takeshi
AU - Kitano, Yotaro
AU - Baba, Yoshinobu
N1 - Funding Information:
This research was supported by the Grant-in-Aid for JSPS Fellows 20J15564, the JSPS Grant-in-Aid for Scientific Research (S) 18H05243 and (B) 18H02009, and the PRESTO JPMJPR19H9, Japan Science and Technology Agency (JST).
Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Driven by the importance of urinary cell-free DNA (cfDNA) as cancer biomarkers, the effectiveness of cfDNA isolation from body fluids can impact clinical usability, especially for molecular diagnostic. However, cfDNA isolations are currently hampered by the dilution of small fragmented cfDNA in body fluids. In this work, we report the unique properties of nanowires assisting the isolation of urinary cfDNA based on specific chemical interactions, maximizing the effectiveness of the platform that could never be achieved with the conventional methods.
AB - Driven by the importance of urinary cell-free DNA (cfDNA) as cancer biomarkers, the effectiveness of cfDNA isolation from body fluids can impact clinical usability, especially for molecular diagnostic. However, cfDNA isolations are currently hampered by the dilution of small fragmented cfDNA in body fluids. In this work, we report the unique properties of nanowires assisting the isolation of urinary cfDNA based on specific chemical interactions, maximizing the effectiveness of the platform that could never be achieved with the conventional methods.
KW - Cell-free DNA
KW - Glass
KW - Liquid-biopsy
KW - Nanowires
KW - Nucleic acid isolation
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M3 - Conference contribution
AN - SCOPUS:85136980149
T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1401
EP - 1402
BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Y2 - 10 October 2021 through 14 October 2021
ER -
