Glioblastoma with ovarian teratoma having N-methyl-D-aspartate receptor (NMDAR) antibody in CSF-A case report

Hiroki Fujii; Satoshi Kubo; Taijun Yunoki; Kota Sato; Kazuhiro Takamatsu; Keiko Tanaka; Yukitoshi Takahashi; Masaru Kuriyama

doi:10.5692/clinicalneurol.53.712

Glioblastoma with ovarian teratoma having N-methyl-D-aspartate receptor (NMDAR) antibody in CSF-A case report

Hiroki Fujii, Satoshi Kubo, Taijun Yunoki, Kota Sato, Kazuhiro Takamatsu, Keiko Tanaka, Yukitoshi Takahashi, Masaru Kuriyama

University Hospital

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A 54-year-old woman presented with complex partial seizure with impaired consciousness. Brain MRI revealed a high intensity lesion on T ₂-weighted and FLAIR images in the left temporal lobe, indicating limbic encephalitis. CT and MRI of the pelvis showed right ovarian teratoma. The cerebrospinal fluid (CSF) were positive for antibodies against the GluRε 2, GluRδ 2, and antibodies against NR1 + NR2B heteromers. On the basis of these data, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis associated with ovarian teratoma was suspected, and the right ovariectomy was performed. Six months after onset, brain biopsy from the right temporal lobe led to a diagnosed of glioblastoma. This is the first glioblastoma case with ovarian teratoma having autoantibodies against GluR and NR1 + NR2B heteromers in CSF. We suggest that patients with NMDAR antibodies should be carefully diagnosed with anti-NMDAR encephalitis.

Original language	English
Pages (from-to)	712-715
Number of pages	4
Journal	Clinical Neurology
Volume	53
Issue number	9
DOIs	https://doi.org/10.5692/clinicalneurol.53.712
Publication status	Published - Sept 1 2013

Keywords

Anti-N-methyl-D-aspartate receptor antibody
Glioblastoma
Limbic encephalitis
Ovarian teratoma

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.5692/clinicalneurol.53.712

Cite this

@article{2e8158740c6d45bd989e117cb01af08a,

title = "Glioblastoma with ovarian teratoma having N-methyl-D-aspartate receptor (NMDAR) antibody in CSF-A case report",

abstract = "A 54-year-old woman presented with complex partial seizure with impaired consciousness. Brain MRI revealed a high intensity lesion on T 2-weighted and FLAIR images in the left temporal lobe, indicating limbic encephalitis. CT and MRI of the pelvis showed right ovarian teratoma. The cerebrospinal fluid (CSF) were positive for antibodies against the GluRε 2, GluRδ 2, and antibodies against NR1 + NR2B heteromers. On the basis of these data, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis associated with ovarian teratoma was suspected, and the right ovariectomy was performed. Six months after onset, brain biopsy from the right temporal lobe led to a diagnosed of glioblastoma. This is the first glioblastoma case with ovarian teratoma having autoantibodies against GluR and NR1 + NR2B heteromers in CSF. We suggest that patients with NMDAR antibodies should be carefully diagnosed with anti-NMDAR encephalitis.",

keywords = "Anti-N-methyl-D-aspartate receptor antibody, Glioblastoma, Limbic encephalitis, Ovarian teratoma",

author = "Hiroki Fujii and Satoshi Kubo and Taijun Yunoki and Kota Sato and Kazuhiro Takamatsu and Keiko Tanaka and Yukitoshi Takahashi and Masaru Kuriyama",

year = "2013",

month = sep,

day = "1",

doi = "10.5692/clinicalneurol.53.712",

language = "English",

volume = "53",

pages = "712--715",

journal = "Clinical Neurology",

issn = "0009-918X",

publisher = "Societas Neurologica Japonica",

number = "9",

}

TY - JOUR

T1 - Glioblastoma with ovarian teratoma having N-methyl-D-aspartate receptor (NMDAR) antibody in CSF-A case report

AU - Fujii, Hiroki

AU - Kubo, Satoshi

AU - Yunoki, Taijun

AU - Sato, Kota

AU - Takamatsu, Kazuhiro

AU - Tanaka, Keiko

AU - Takahashi, Yukitoshi

AU - Kuriyama, Masaru

PY - 2013/9/1

Y1 - 2013/9/1

N2 - A 54-year-old woman presented with complex partial seizure with impaired consciousness. Brain MRI revealed a high intensity lesion on T 2-weighted and FLAIR images in the left temporal lobe, indicating limbic encephalitis. CT and MRI of the pelvis showed right ovarian teratoma. The cerebrospinal fluid (CSF) were positive for antibodies against the GluRε 2, GluRδ 2, and antibodies against NR1 + NR2B heteromers. On the basis of these data, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis associated with ovarian teratoma was suspected, and the right ovariectomy was performed. Six months after onset, brain biopsy from the right temporal lobe led to a diagnosed of glioblastoma. This is the first glioblastoma case with ovarian teratoma having autoantibodies against GluR and NR1 + NR2B heteromers in CSF. We suggest that patients with NMDAR antibodies should be carefully diagnosed with anti-NMDAR encephalitis.

AB - A 54-year-old woman presented with complex partial seizure with impaired consciousness. Brain MRI revealed a high intensity lesion on T 2-weighted and FLAIR images in the left temporal lobe, indicating limbic encephalitis. CT and MRI of the pelvis showed right ovarian teratoma. The cerebrospinal fluid (CSF) were positive for antibodies against the GluRε 2, GluRδ 2, and antibodies against NR1 + NR2B heteromers. On the basis of these data, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis associated with ovarian teratoma was suspected, and the right ovariectomy was performed. Six months after onset, brain biopsy from the right temporal lobe led to a diagnosed of glioblastoma. This is the first glioblastoma case with ovarian teratoma having autoantibodies against GluR and NR1 + NR2B heteromers in CSF. We suggest that patients with NMDAR antibodies should be carefully diagnosed with anti-NMDAR encephalitis.

KW - Anti-N-methyl-D-aspartate receptor antibody

KW - Glioblastoma

KW - Limbic encephalitis

KW - Ovarian teratoma

UR - http://www.scopus.com/inward/record.url?scp=84884317886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884317886&partnerID=8YFLogxK

U2 - 10.5692/clinicalneurol.53.712

DO - 10.5692/clinicalneurol.53.712

M3 - Article

C2 - 24097319

AN - SCOPUS:84884317886

SN - 0009-918X

VL - 53

SP - 712

EP - 715

JO - Clinical Neurology

JF - Clinical Neurology

IS - 9

ER -

Glioblastoma with ovarian teratoma having N-methyl-D-aspartate receptor (NMDAR) antibody in CSF-A case report

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this