Glucose non-fermentative gram-negative rods isolated from complicated urinary tract infections

During the 16-year period from 1971 to 1986, 317 strains of glucose non-fermentative Gram-negative rods (NF-GNR), excluding P. aeruginosa, were isolated from in-patients with complicated urinary tract infection (UTI) in the Department of Urology, Okayama University Hospital. 1) The annual incidence of NF-GNR increased gradually up to more than 10% of the total strains isolated from complicated UTI since 1979. 2) NF-GNR were isolated frequently from patients with polymicrobial infection (40.3%) and indwelling catheter (61.9%). 3) Most patients had no clinical symptoms in spite of the isolation of NF-GNR. The grade of pyuria in patients with NF-GNR infection was lower than that in patients with other kinds of bacteria, such as E. coli, Proteus spp., P. aeruginosa, and Serratia spp. 4) Concerning previous chemotherapy, about 85% of the patients had received chemotherapy. 5) More than 60% of isolates disappeared after chemotherapy, although almost all cases were treated with drugs against which NF-GNR are insensitive. 6) In recent years, drug sensitivity of NF-GNR has gradually decreased, including sensitivity against ST, MINO, and aminoglycosides.