TY - JOUR
T1 - Golfomycin A, a Novel Designed Molecule with DNA‐Cleaving Properties and Antitumor Activity
AU - Nicolaou, K. C.
AU - Skokotas, Golfo
AU - Furuya, S.
AU - Suemune, H.
AU - Nicolaou, D. Colette
PY - 1990/9
Y1 - 1990/9
N2 - Retroaldol reaction, propargyl–allenyl isomerization, and [4 + 2] cycloaddition are the steps involved in the reaction of the title compound 1 with 1,8‐diazabi‐cyclo[5.4.0]undec‐7‐ene at room temperature in THF. The product 2, like 1, reacts readily with nucleophiles such as methyl thioglycolate. The biological activity of these compounds is presumably due to this reactivity. (Figure Presented.)
AB - Retroaldol reaction, propargyl–allenyl isomerization, and [4 + 2] cycloaddition are the steps involved in the reaction of the title compound 1 with 1,8‐diazabi‐cyclo[5.4.0]undec‐7‐ene at room temperature in THF. The product 2, like 1, reacts readily with nucleophiles such as methyl thioglycolate. The biological activity of these compounds is presumably due to this reactivity. (Figure Presented.)
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U2 - 10.1002/anie.199010641
DO - 10.1002/anie.199010641
M3 - Article
AN - SCOPUS:0025146385
SN - 0570-0833
VL - 29
SP - 1064
EP - 1067
JO - Angewandte Chemie International Edition in English
JF - Angewandte Chemie International Edition in English
IS - 9
ER -