Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor

Hitomi Higuchi; Shota Yamamoto; Soichiro Ushio; Takehiro Kawashiri; Nobuaki Egashira

doi:10.1016/j.jphs.2015.09.004

Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor

Hitomi Higuchi, Shota Yamamoto, Soichiro Ushio, Takehiro Kawashiri, Nobuaki Egashira

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

In the present study, we investigated the effect of a Kampo medicine Goshajinkigan (GJG) on the bortezomib-induced mechanical allodynia in von Frey test in rats. The single administration of tramadol (10 mg/kg), GJG (1.0 g/kg) and its component processed Aconiti tuber (0.1 g/kg) significantly reversed the reduction in withdrawal threshold by bortezomib. These effects were abolished by the intrathecal injection of nor-binaltorphimine (10 μg/body), kappa opioid receptor antagonist. These findings suggest that kappa opioid receptor is involved in the effect of GJG on the bortezomib-induced mechanical allodynia.

Original language	English
Pages (from-to)	196-199
Number of pages	4
Journal	Journal of Pharmacological Sciences
Volume	129
Issue number	3
DOIs	https://doi.org/10.1016/j.jphs.2015.09.004
Publication status	Published - Nov 1 2015
Externally published	Yes

Keywords

Bortezomib
Goshajinkigan
Peripheral neuropathy

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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10.1016/j.jphs.2015.09.004

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title = "Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor",

abstract = "In the present study, we investigated the effect of a Kampo medicine Goshajinkigan (GJG) on the bortezomib-induced mechanical allodynia in von Frey test in rats. The single administration of tramadol (10 mg/kg), GJG (1.0 g/kg) and its component processed Aconiti tuber (0.1 g/kg) significantly reversed the reduction in withdrawal threshold by bortezomib. These effects were abolished by the intrathecal injection of nor-binaltorphimine (10 μg/body), kappa opioid receptor antagonist. These findings suggest that kappa opioid receptor is involved in the effect of GJG on the bortezomib-induced mechanical allodynia.",

keywords = "Bortezomib, Goshajinkigan, Peripheral neuropathy",

author = "Hitomi Higuchi and Shota Yamamoto and Soichiro Ushio and Takehiro Kawashiri and Nobuaki Egashira",

note = "Funding Information: Part of this study was supported by JSPS KAKENHI Grant Numbers 25460335 and 25870496 . We are grateful to Tsumura & Co. for providing GJG for this study. Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

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doi = "10.1016/j.jphs.2015.09.004",

language = "English",

volume = "129",

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T2 - Possible involvement of kappa opioid receptor

AU - Higuchi, Hitomi

AU - Yamamoto, Shota

AU - Ushio, Soichiro

AU - Kawashiri, Takehiro

AU - Egashira, Nobuaki

N1 - Funding Information: Part of this study was supported by JSPS KAKENHI Grant Numbers 25460335 and 25870496 . We are grateful to Tsumura & Co. for providing GJG for this study. Publisher Copyright: © 2015 The Authors.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - In the present study, we investigated the effect of a Kampo medicine Goshajinkigan (GJG) on the bortezomib-induced mechanical allodynia in von Frey test in rats. The single administration of tramadol (10 mg/kg), GJG (1.0 g/kg) and its component processed Aconiti tuber (0.1 g/kg) significantly reversed the reduction in withdrawal threshold by bortezomib. These effects were abolished by the intrathecal injection of nor-binaltorphimine (10 μg/body), kappa opioid receptor antagonist. These findings suggest that kappa opioid receptor is involved in the effect of GJG on the bortezomib-induced mechanical allodynia.

AB - In the present study, we investigated the effect of a Kampo medicine Goshajinkigan (GJG) on the bortezomib-induced mechanical allodynia in von Frey test in rats. The single administration of tramadol (10 mg/kg), GJG (1.0 g/kg) and its component processed Aconiti tuber (0.1 g/kg) significantly reversed the reduction in withdrawal threshold by bortezomib. These effects were abolished by the intrathecal injection of nor-binaltorphimine (10 μg/body), kappa opioid receptor antagonist. These findings suggest that kappa opioid receptor is involved in the effect of GJG on the bortezomib-induced mechanical allodynia.

KW - Bortezomib

KW - Goshajinkigan

KW - Peripheral neuropathy

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JF - Journal of Pharmacological Sciences

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ER -

Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor

Abstract

Keywords

ASJC Scopus subject areas

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