Hadamard transform capillary electrophoresis

Takashi Kaneta, Yasuko Yamaguchi, Totaro Imasaka

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)


This paper reports the first demonstration of a multiplex sample injection technique in capillary electrophoresis. The sample was injected into a capillary (effective length, 4 cm) as a pseudorandam Hadamard sequence by a photodegradation technique using a high-power gating laser, and the fluorescence signal, which was measured using a probe excitation beam, was decoded by an inverse Hadamard transformation. The signal-to-noise ratio was improved by a factor of 8, which was in good agreement with the theoretically predicted value of 8.02. This approach is potentially useful for the enhancement of the sensitivity by 3 orders of magnitude in high-resolution capillary electrophoresis, combined with fluorescence detection.

Original languageEnglish
Pages (from-to)5444-5446
Number of pages3
JournalAnalytical Chemistry
Issue number23
Publication statusPublished - Dec 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry


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