Hadamard transform microchip electrophoresis combined with diode laser fluorometry

Kazuki Hata, Yasuhiko Kichise, Takashi Kaneta, Totaro Imasaka

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


The application of a Hadamard transform technique to microchip electrophoresis is described. The sample is electrokinetically injected into a separation channel and is then detected by diode laser-induced fluorometry. The sample and buffer solutions are introduced into the channel by controlling the high voltages applied to the solutions, according to a code determined by a Hadamard matrix. The S/N ratio of the signal in the electropherogram can be improved by a factor of 5 in comparison with that obtained by a conventional single-injection method, although an 8-fold improvement is theoretically predicted when a 255-order matrix is used.

Original languageEnglish
Pages (from-to)1765-1768
Number of pages4
JournalAnalytical Chemistry
Issue number7
Publication statusPublished - Apr 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry


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