Halichonadins K and L, new dimeric sesquiterpenoids from a sponge Halichondria sp.

Naonobu Tanaka; Shohei Suto; Haruaki Ishiyama; Takaaki Kubota; Akihito Yamano; Motoo Shiro; Jane Fromont; Jun'Ichi Kobayashi

doi:10.1021/ol3014705

Halichonadins K and L, new dimeric sesquiterpenoids from a sponge Halichondria sp.

Naonobu Tanaka, Shohei Suto, Haruaki Ishiyama, Takaaki Kubota, Akihito Yamano, Motoo Shiro, Jane Fromont, Jun'Ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Two new structurally unique dimeric sesquiterpenoids, halichonadins K (1) and L (2), were isolated from an Okinawan marine sponge Halichondria sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis including a single crystal X-ray diffraction analysis and chemical conversion. Halichonadins K (1) and L (2) are homodimers of the eudesmane sesquiterpene linked with a piperidine ring through amide bonds. Halichonadin K (1) showed moderate cytotoxicity against KB cells.

Original language	English
Pages (from-to)	3498-3501
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	13
DOIs	https://doi.org/10.1021/ol3014705
Publication status	Published - Jul 6 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "Two new structurally unique dimeric sesquiterpenoids, halichonadins K (1) and L (2), were isolated from an Okinawan marine sponge Halichondria sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis including a single crystal X-ray diffraction analysis and chemical conversion. Halichonadins K (1) and L (2) are homodimers of the eudesmane sesquiterpene linked with a piperidine ring through amide bonds. Halichonadin K (1) showed moderate cytotoxicity against KB cells.",

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T1 - Halichonadins K and L, new dimeric sesquiterpenoids from a sponge Halichondria sp.

AU - Tanaka, Naonobu

AU - Suto, Shohei

AU - Ishiyama, Haruaki

AU - Kubota, Takaaki

AU - Yamano, Akihito

AU - Shiro, Motoo

AU - Fromont, Jane

AU - Kobayashi, Jun'Ichi

PY - 2012/7/6

Y1 - 2012/7/6

N2 - Two new structurally unique dimeric sesquiterpenoids, halichonadins K (1) and L (2), were isolated from an Okinawan marine sponge Halichondria sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis including a single crystal X-ray diffraction analysis and chemical conversion. Halichonadins K (1) and L (2) are homodimers of the eudesmane sesquiterpene linked with a piperidine ring through amide bonds. Halichonadin K (1) showed moderate cytotoxicity against KB cells.

AB - Two new structurally unique dimeric sesquiterpenoids, halichonadins K (1) and L (2), were isolated from an Okinawan marine sponge Halichondria sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis including a single crystal X-ray diffraction analysis and chemical conversion. Halichonadins K (1) and L (2) are homodimers of the eudesmane sesquiterpene linked with a piperidine ring through amide bonds. Halichonadin K (1) showed moderate cytotoxicity against KB cells.

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Halichonadins K and L, new dimeric sesquiterpenoids from a sponge Halichondria sp.

Abstract

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