HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3

Shin ichi Toyooka, Mamoru Ouchida, Yoshimi Jitsumori, Kazunori Tsukuda, Akiko Sakai, Akio Nakamura, Nobuyoshi Shimizu, Kenji Shimizu

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


A human cDNA encoding a novel protein tyrosine phosphatase has been isolated. The phosphatase has unique features in its domain structure: a 'Zn-hand' domain containing several SH3-binding motifs, a tyrosine phosphatase domain, a C-terminal PEST motif, and an N-terminal domain similar to yeast BRO1, an apoptosis-related mammalian AIP1 and to a RHO-binding protein, Rhophilin. The gene is located at chromosome 3p21.3, an area frequently deleted in many types of cancer, especially within the functionally defined narrow region. The gene may be a human homolog of the rat PTP-TD14 gene reported by others, which can suppress H-ras-mediated transformation. We identified a hemizygous missense mutation in a lung cancer cell line. Thus, the phosphatase gene may be a candidate for one of the tumor suppressor genes located on 3p21.3. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)671-678
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - Nov 30 2000


  • Apoptosis
  • Chromosome 3p21
  • Lung cancer
  • Protein tyrosine phosphatase
  • Signaling
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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