TY - JOUR
T1 - HD-PTP
T2 - A novel protein tyrosine phosphatase gene on human chromosome 3p21.3
AU - Toyooka, Shin ichi
AU - Ouchida, Mamoru
AU - Jitsumori, Yoshimi
AU - Tsukuda, Kazunori
AU - Sakai, Akiko
AU - Nakamura, Akio
AU - Shimizu, Nobuyoshi
AU - Shimizu, Kenji
N1 - Funding Information:
We thank Dr. J. Yokota for kindly supplying DNAs of human SCLC cell lines. We also thank Drs. M. Go and S. Nakamura of Nagoya University (Nagoya, Japan) for helpful advises as to the tertiary structure of the HD-PTP. This work was supported by Grants-in-Aids from the Ministry of Education, Science, Sports, and Culture and from the Ministry of Health and Welfare, Japan, to K.S.
PY - 2000/11/30
Y1 - 2000/11/30
N2 - A human cDNA encoding a novel protein tyrosine phosphatase has been isolated. The phosphatase has unique features in its domain structure: a 'Zn-hand' domain containing several SH3-binding motifs, a tyrosine phosphatase domain, a C-terminal PEST motif, and an N-terminal domain similar to yeast BRO1, an apoptosis-related mammalian AIP1 and to a RHO-binding protein, Rhophilin. The gene is located at chromosome 3p21.3, an area frequently deleted in many types of cancer, especially within the functionally defined narrow region. The gene may be a human homolog of the rat PTP-TD14 gene reported by others, which can suppress H-ras-mediated transformation. We identified a hemizygous missense mutation in a lung cancer cell line. Thus, the phosphatase gene may be a candidate for one of the tumor suppressor genes located on 3p21.3. (C) 2000 Academic Press.
AB - A human cDNA encoding a novel protein tyrosine phosphatase has been isolated. The phosphatase has unique features in its domain structure: a 'Zn-hand' domain containing several SH3-binding motifs, a tyrosine phosphatase domain, a C-terminal PEST motif, and an N-terminal domain similar to yeast BRO1, an apoptosis-related mammalian AIP1 and to a RHO-binding protein, Rhophilin. The gene is located at chromosome 3p21.3, an area frequently deleted in many types of cancer, especially within the functionally defined narrow region. The gene may be a human homolog of the rat PTP-TD14 gene reported by others, which can suppress H-ras-mediated transformation. We identified a hemizygous missense mutation in a lung cancer cell line. Thus, the phosphatase gene may be a candidate for one of the tumor suppressor genes located on 3p21.3. (C) 2000 Academic Press.
KW - Apoptosis
KW - Chromosome 3p21
KW - Lung cancer
KW - Protein tyrosine phosphatase
KW - Signaling
KW - Tumor suppressor gene
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U2 - 10.1006/bbrc.2000.3870
DO - 10.1006/bbrc.2000.3870
M3 - Article
C2 - 11095967
AN - SCOPUS:0034736056
SN - 0006-291X
VL - 278
SP - 671
EP - 678
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -
