@article{4a56ef8ba75c4cfdbf424c6aba13d982,
title = "Heat stress influences the attenuation of prostaglandin synthesis by interferon tau in bovine endometrial cells",
abstract = "Heat stress (HS) reduces reproductive performance of cattle, possibly by disrupting endocrine regulation such as prostaglandin (PG) production from uterus and estradiol 17β production from the dominant follicle. Prostaglandin F2α (PGF2α) secretion from endometrium surges during the luteal phase due to tumor necrosis factor (TNF) α stimulation and a positive-feedback loop with oxytocin (OT) from the corpus luteum, ultimately triggering luteolysis, while interferon τ (IFNT) inhibits upregulation of PGF2α production by TNFα and OT, thereby preventing luteolysis and triggering recognition of pregnancy. In the present study, we investigated the effect of OT, TNFα, and IFNT on PGF2α production in both types of endometrial cells under HS conditions. Stimulation of PGF2α production in endometrial epithelial cells by OT was unaffected by HS, while stimulation of PGF2α production in endometrial stromal cells by TNFα was enhanced by HS, and this increased PGF2α production was not significantly suppressed by IFNT. These results suggest that HS disrupted the regulation of PGF2α production by TNFα and IFNT in bovine endometrial stromal cells and it might be one of causes for low conception rate of cattle in summer.",
keywords = "Cattle, Endometrial, Heat stress, Interferon tau, Prostaglandin",
author = "Shunsuke Sakai and Mami Yagi and Nao Fujime and Mariko Kuse and Ryosuke Sakumoto and Yuki Yamamoto and Kiyoshi Okuda and Koji Kimura",
note = "Funding Information: This work was supported by the Grants-in-Aid for Research Program on Innovative Technologies for Animal Breeding, Reproduction, and Vaccine Development (REP-1002) from the Ministry of Agriculture , Forestry, and Fisheries of Japan, JSPS KAKENHI Grant Number 19H03105 and 20K21372 , and Cooperative Research Grant of the Genome Research for BioResource, NODAI Genome Research Center, Tokyo University of Agriculture . We greatly appreciate Okayama Meat Center (Okayama, Japan) for providing the bovine uteri, Teikoku Hormone MFG Co. (Tokyo, Japan) for OT, and Dainippon Pharmaceutical Co. Ltd. (Osaka, Japan) for recombinant human TNFα. Funding Information: This work was supported by the Grants-in-Aid for Research Program on Innovative Technologies for Animal Breeding, Reproduction, and Vaccine Development (REP-1002) from the Ministry of Agriculture, Forestry, and Fisheries of Japan, JSPS KAKENHI Grant Number 19H03105 and 20K21372, and Cooperative Research Grant of the Genome Research for BioResource, NODAI Genome Research Center, Tokyo University of Agriculture. We greatly appreciate Okayama Meat Center (Okayama, Japan) for providing the bovine uteri, Teikoku Hormone MFG Co. (Tokyo, Japan) for OT, and Dainippon Pharmaceutical Co. Ltd. (Osaka, Japan) for recombinant human TNF?. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = apr,
day = "15",
doi = "10.1016/j.theriogenology.2021.02.005",
language = "English",
volume = "165",
pages = "52--58",
journal = "Theriogenology",
issn = "0093-691X",
publisher = "Elsevier Inc.",
}