Heavy metals in blood and urine and its relation to depressive symptoms in Parkinson's disease patients

Tetsuhito Fukushima; Xiaodong Tan; Yunwen Luo; Puqing Wang; Jinhui Song; Hideyuki Kanda; Takehito Hayakawa; Tomohiro Kumagai; Takeyasu Kakamu; Masayoshi Tsuji; Tomoo Hidaka; Yayoi Mori

doi:10.5387/fms.59.76

Heavy metals in blood and urine and its relation to depressive symptoms in Parkinson's disease patients

Tetsuhito Fukushima, Xiaodong Tan, Yunwen Luo, Puqing Wang, Jinhui Song, Hideyuki Kanda, Takehito Hayakawa, Tomohiro Kumagai, Takeyasu Kakamu, Masayoshi Tsuji, Tomoo Hidaka, Yayoi Mori

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

OBJECTIVES: Some heavy metals are suspected to be pathogenic to both Parkinson's disease (PD) and depression. Common background may exist in them.

METHODS: Subjects comprised PD patients with depression, PD patients without depression and controls recruited from the outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals and vitamins.

RESULTS: Whole-blood manganese was significantly higher in the PD patients without depression than in both the PD patients with depression and the controls. Serum iron was significantly higher in the PD patients without depression than in the controls. Urine iron was also significantly higher in the PD patients without depression than in the controls. Serum copper was significantly lower in the PD patients with depression than in both the PD patients without depression and the controls.

CONCLUSIONS: Excessive intake of iron and accumulation of manganese seemed to be involved in the etiology of non-depressive PD.

Original language	English
Pages (from-to)	76-80
Number of pages	5
Journal	Fukushima journal of medical science
Volume	59
Issue number	2
DOIs	https://doi.org/10.5387/fms.59.76
Publication status	Published - 2013
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.5387/fms.59.76

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title = "Heavy metals in blood and urine and its relation to depressive symptoms in Parkinson's disease patients",

abstract = "OBJECTIVES: Some heavy metals are suspected to be pathogenic to both Parkinson's disease (PD) and depression. Common background may exist in them.METHODS: Subjects comprised PD patients with depression, PD patients without depression and controls recruited from the outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals and vitamins.RESULTS: Whole-blood manganese was significantly higher in the PD patients without depression than in both the PD patients with depression and the controls. Serum iron was significantly higher in the PD patients without depression than in the controls. Urine iron was also significantly higher in the PD patients without depression than in the controls. Serum copper was significantly lower in the PD patients with depression than in both the PD patients without depression and the controls.CONCLUSIONS: Excessive intake of iron and accumulation of manganese seemed to be involved in the etiology of non-depressive PD.",

author = "Tetsuhito Fukushima and Xiaodong Tan and Yunwen Luo and Puqing Wang and Jinhui Song and Hideyuki Kanda and Takehito Hayakawa and Tomohiro Kumagai and Takeyasu Kakamu and Masayoshi Tsuji and Tomoo Hidaka and Yayoi Mori",

year = "2013",

doi = "10.5387/fms.59.76",

language = "English",

volume = "59",

pages = "76--80",

journal = "Fukushima Journal of Medical Sciences",

issn = "0016-2590",

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number = "2",

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TY - JOUR

T1 - Heavy metals in blood and urine and its relation to depressive symptoms in Parkinson's disease patients

AU - Fukushima, Tetsuhito

AU - Tan, Xiaodong

AU - Luo, Yunwen

AU - Wang, Puqing

AU - Song, Jinhui

AU - Kanda, Hideyuki

AU - Hayakawa, Takehito

AU - Kumagai, Tomohiro

AU - Kakamu, Takeyasu

AU - Tsuji, Masayoshi

AU - Hidaka, Tomoo

AU - Mori, Yayoi

PY - 2013

Y1 - 2013

N2 - OBJECTIVES: Some heavy metals are suspected to be pathogenic to both Parkinson's disease (PD) and depression. Common background may exist in them.METHODS: Subjects comprised PD patients with depression, PD patients without depression and controls recruited from the outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals and vitamins.RESULTS: Whole-blood manganese was significantly higher in the PD patients without depression than in both the PD patients with depression and the controls. Serum iron was significantly higher in the PD patients without depression than in the controls. Urine iron was also significantly higher in the PD patients without depression than in the controls. Serum copper was significantly lower in the PD patients with depression than in both the PD patients without depression and the controls.CONCLUSIONS: Excessive intake of iron and accumulation of manganese seemed to be involved in the etiology of non-depressive PD.

AB - OBJECTIVES: Some heavy metals are suspected to be pathogenic to both Parkinson's disease (PD) and depression. Common background may exist in them.METHODS: Subjects comprised PD patients with depression, PD patients without depression and controls recruited from the outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals and vitamins.RESULTS: Whole-blood manganese was significantly higher in the PD patients without depression than in both the PD patients with depression and the controls. Serum iron was significantly higher in the PD patients without depression than in the controls. Urine iron was also significantly higher in the PD patients without depression than in the controls. Serum copper was significantly lower in the PD patients with depression than in both the PD patients without depression and the controls.CONCLUSIONS: Excessive intake of iron and accumulation of manganese seemed to be involved in the etiology of non-depressive PD.

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JO - Fukushima Journal of Medical Sciences

JF - Fukushima Journal of Medical Sciences

IS - 2

ER -

Heavy metals in blood and urine and its relation to depressive symptoms in Parkinson's disease patients

Abstract

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