Helicobacter pylori Induces Inflammation in Mouse Urinary Bladder and Pelvis

Hiroshi Isogai, Koichi Kimura, Nobuhiro Fujii, Emiko Isogai, Kenji Yokota, Keiji Oguma

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Helicobacter pylori was transurethrally inoculated into the mouse urinary tract. The organism established infection and induced inflammation in the urinary bladder and pelvis. During the infection, urinary pH was elevated, probably due to the production of NH3 by bacterial urease. H. pylori was recovered from the urinary bladder, kidney and urine of the infected mice. Histopathologically, severe neutrophil infiltration was observed in the mucosal layer of both organs. H. pylori was detected on the surface of the epithelial cells. These results indicate that low pH and bacterial flora were not essential factors in establishing the mucosal infection with H. pylori. This experimental system is useful to investigate the pathogenicity of H. pylori in mucosal organs.

Original languageEnglish
Pages (from-to)331-336
Number of pages6
Issue number5
Publication statusPublished - 1994


  • Helicobacter pylori
  • Inflammation
  • Kidney
  • Urinary bladder

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology


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