Helicobacter pylori vacuolating cytotoxin, VacA

Toshiya Hirayama, Akihiro Wada, Kinnosuke Yahiro, Miyuki Kimura, Takahiro Kimura

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Helicobacter pylori is the leading bacterial cause of food-borne illness worldwide and plays a major role in the development of chronic gastritis, peptic ulcer, and gastric cancer. Strains isolated from patients contain the cagA gene (cytotoxin-associated gene A) and produce the vacuolating cytotoxin, VacA. Recent molecular and cellular studies of VacA action have begun to unravel its structure and the details of the mechanism of gastric injury caused by H. pylori infection.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalJapanese journal of infectious diseases
Issue number1
Publication statusPublished - Jun 5 2002

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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