Heme oxygenase-1: A fundamental guardian against oxidative tissue injuries in acute inflammation

Takatoru Takahashi; H. Shimizu; H. Morimatsu; K. Inoue; R. Akagi; K. Morita; S. Sassa

doi:10.2174/138955707781024517

Heme oxygenase-1: A fundamental guardian against oxidative tissue injuries in acute inflammation

Takatoru Takahashi, H. Shimizu, H. Morimatsu, K. Inoue, R. Akagi, K. Morita, S. Sassa

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Free heme contributes as a major threat to the oxidative tissue injuries because it catalyzes the formation of reactive oxygen species. When free heme concentration is increased, it results in the induction of heme oxygenase-1 (HO-1), which then breaks free heme down. As such, HO-1 plays a pivotal role in the protection of tissues from oxidative injuries.

Original language	English
Pages (from-to)	745-753
Number of pages	9
Journal	Mini-Reviews in Medicinal Chemistry
Volume	7
Issue number	7
DOIs	https://doi.org/10.2174/138955707781024517
Publication status	Published - Jul 1 2007

Keywords

Carbon monoxide
Heme
Heme oxygenase-1
Inflammation
Liver injury
Oxidative stress
Renal injury
Sepsis

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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abstract = "Free heme contributes as a major threat to the oxidative tissue injuries because it catalyzes the formation of reactive oxygen species. When free heme concentration is increased, it results in the induction of heme oxygenase-1 (HO-1), which then breaks free heme down. As such, HO-1 plays a pivotal role in the protection of tissues from oxidative injuries.",

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AU - Takahashi, Takatoru

AU - Shimizu, H.

AU - Morimatsu, H.

AU - Inoue, K.

AU - Akagi, R.

AU - Morita, K.

AU - Sassa, S.

PY - 2007/7/1

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AB - Free heme contributes as a major threat to the oxidative tissue injuries because it catalyzes the formation of reactive oxygen species. When free heme concentration is increased, it results in the induction of heme oxygenase-1 (HO-1), which then breaks free heme down. As such, HO-1 plays a pivotal role in the protection of tissues from oxidative injuries.

KW - Carbon monoxide

KW - Heme

KW - Heme oxygenase-1

KW - Inflammation

KW - Liver injury

KW - Oxidative stress

KW - Renal injury

KW - Sepsis

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Heme oxygenase-1: A fundamental guardian against oxidative tissue injuries in acute inflammation

Abstract

Keywords

ASJC Scopus subject areas

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