Hepatopulmonary syndrome in Japanese liver cirrhosis patients

Hayami Okada, Akinobu Takaki, Takahito Yagi, Tetsuya Yasunaka, Tatsuhiro Gotoda, Hiroki Oe, Kazufumi Nakamura, Shuichi Sato, Hiroshi Sadamori, Susumu Shinoura, Yuzo Umeda, Ryuichi Yoshida, Masashi Utsumi, Daisuke Nobuoka, Yuko Yasuda, Fusao Ikeda, Yasuhiro Miyake, Hiroshi Ito, Toshiyoshi Fujiwara, Kazuhide Yamamoto

Research output: Contribution to journalArticlepeer-review


Hepatopulmonary syndrome is characterized by hypoxemia induced by intrapulmonary vascular dilatations associated with hepatic diseases. We evaluated the frequency and case presentations revealed by general screening before liver transplantation. Sixty-one patients underwent arterial blood gas analysis in both upright and supine positions. Of these, 27 patients (44%) showed Pa02 <80 mmHg and AaD02 >15 mmHg, reflecting intrapulmonary shunting. Four patients exhibited Pa02 < 70 mmHg and orthodeoxia, defined as a fall in Pa02 >5% or 4 mmHg in an upright position. Finally, two patients showed hepatopulmonary syndrome, with positive findings on perfusion lung scanning. Both patients with hepatopulmonary syndrome had liver cirrhosis type C with habitual alcohol drinking and smoking. Potential pulmonary shunt patients with Pa02 < 80 mmHg and AaD02 >15 mmHg exhibited higher model for end-stage liver disease scores. Care should be taken regarding hepatopulmonary syndrome during liver cirrhosis management in Japanese patients.

Original languageEnglish
Pages (from-to)143-154
Number of pages12
JournalKanzo/Acta Hepatologica Japonica
Issue number3
Publication statusPublished - 2014


  • Blood gas analysis
  • Hepatopulmonary syndrome
  • Hypoxemia
  • Liver cirrhosis
  • Liver transplantation

ASJC Scopus subject areas

  • Hepatology


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