Hepatotoxicity of hydrazine in isolated rat hepatocytes

Toshiaki Sendo; Atsuko Noda; Kohji Ohno; Shigeru Goto; Hiroshi Noda

doi:10.1248/cpb.32.795

Hepatotoxicity of hydrazine in isolated rat hepatocytes

Toshiaki Sendo, Atsuko Noda, Kohji Ohno, Shigeru Goto, Hiroshi Noda

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Cytotoxicity of hydrazine (Hz) and acetylhydrazine (AcHz) was investigated using isolated rat hepatocytes. 10, 10 and 10 M of Hz decreased hepatocellular reduced glutathione (GSH) in a strongly dose-dependent manner, while AcHz showed little effect on the GSH levels at any concentration examined. The results reveal that Hz is more hepatotoxic than AcHz.

Original language	English
Pages (from-to)	795-796
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	32
Issue number	2
DOIs	https://doi.org/10.1248/cpb.32.795
Publication status	Published - Jan 1 1984
Externally published	Yes

Keywords

acetylhydrazine
hydrazine
isolated rat hepatocyte system
reduced glutathione

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.32.795

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abstract = "Cytotoxicity of hydrazine (Hz) and acetylhydrazine (AcHz) was investigated using isolated rat hepatocytes. 10, 10 and 10 M of Hz decreased hepatocellular reduced glutathione (GSH) in a strongly dose-dependent manner, while AcHz showed little effect on the GSH levels at any concentration examined. The results reveal that Hz is more hepatotoxic than AcHz.",

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author = "Toshiaki Sendo and Atsuko Noda and Kohji Ohno and Shigeru Goto and Hiroshi Noda",

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AU - Sendo, Toshiaki

AU - Noda, Atsuko

AU - Ohno, Kohji

AU - Goto, Shigeru

AU - Noda, Hiroshi

PY - 1984/1/1

Y1 - 1984/1/1

N2 - Cytotoxicity of hydrazine (Hz) and acetylhydrazine (AcHz) was investigated using isolated rat hepatocytes. 10, 10 and 10 M of Hz decreased hepatocellular reduced glutathione (GSH) in a strongly dose-dependent manner, while AcHz showed little effect on the GSH levels at any concentration examined. The results reveal that Hz is more hepatotoxic than AcHz.

AB - Cytotoxicity of hydrazine (Hz) and acetylhydrazine (AcHz) was investigated using isolated rat hepatocytes. 10, 10 and 10 M of Hz decreased hepatocellular reduced glutathione (GSH) in a strongly dose-dependent manner, while AcHz showed little effect on the GSH levels at any concentration examined. The results reveal that Hz is more hepatotoxic than AcHz.

KW - acetylhydrazine

KW - hydrazine

KW - isolated rat hepatocyte system

KW - reduced glutathione

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ER -

Hepatotoxicity of hydrazine in isolated rat hepatocytes

Abstract

Keywords

ASJC Scopus subject areas

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