TY - JOUR
T1 - Hereditary gynecologic tumors and precision cancer medicine
AU - Ogawa, Chikako
AU - Hirasawa, Akira
AU - Ida, Naoyuki
AU - Nakamura, Keiichiro
AU - Masuyama, Hisashi
N1 - Funding Information:
This research was partly supported by a Health Labour Sciences Research Grant from the Japanese Ministry of Health, Labour and Welfare, (20EA1027), by the Foundation for Promotion of Cancer Research, and by the Kobayashi Foundation for Cancer Research. The funding sources had no role in the design, practice or analysis of this study.
Publisher Copyright:
© 2022 Japan Society of Obstetrics and Gynecology.
PY - 2022/5
Y1 - 2022/5
N2 - Gynecologic cancers are more often caused by genetic factors than other cancers. Genetic testing has become a promising avenue for the prevention, prognosis, and treatment of cancers. This review describes molecular features of gynecologic tumors linked to hereditary syndromes, gives an overview of the current state of clinical management, and clarifies the role of gynecology in the treatment of hereditary tumors. Typical hereditary gynecologic tumors include hereditary breast and ovarian cancer, Lynch syndrome, Peutz–Jeghers syndrome, and Cowden syndrome. Multigene panel testing, which analyzes a preselected subset of genes for genetic variants, has recently become the first-choice test because it can provide more accurate risk assessment than a single test. Furthermore, comprehensive genomic cancer profiling enables personalized cancer treatment and aids in germline findings.
AB - Gynecologic cancers are more often caused by genetic factors than other cancers. Genetic testing has become a promising avenue for the prevention, prognosis, and treatment of cancers. This review describes molecular features of gynecologic tumors linked to hereditary syndromes, gives an overview of the current state of clinical management, and clarifies the role of gynecology in the treatment of hereditary tumors. Typical hereditary gynecologic tumors include hereditary breast and ovarian cancer, Lynch syndrome, Peutz–Jeghers syndrome, and Cowden syndrome. Multigene panel testing, which analyzes a preselected subset of genes for genetic variants, has recently become the first-choice test because it can provide more accurate risk assessment than a single test. Furthermore, comprehensive genomic cancer profiling enables personalized cancer treatment and aids in germline findings.
KW - Cowden syndrome
KW - hereditary breast and ovarian cancer syndrome
KW - homologous recombination deficiency
KW - Lynch syndrome
KW - multigene panel testing
KW - Peutz–Jeghers syndrome
UR - http://www.scopus.com/inward/record.url?scp=85125953238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85125953238&partnerID=8YFLogxK
U2 - 10.1111/jog.15197
DO - 10.1111/jog.15197
M3 - Article
C2 - 35229413
AN - SCOPUS:85125953238
SN - 1341-8076
VL - 48
SP - 1076
EP - 1090
JO - Journal of Obstetrics and Gynaecology Research
JF - Journal of Obstetrics and Gynaecology Research
IS - 5
ER -
