HHV-6 and seizures

Nobuko Yamashita, Tsuneo Morishima

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)


Human herpes virus-6 (HHV-6) is a ubiquitous virus, but one that can induce various neurological diseases. Recently, several seizures have been reported as new HHV-6-associated diseases based on virological analysis. Neonates who are perinatally infected with HHV-6 can develop afebrile seizures, which are considered to be exanthem subitum (ES) in the neonatal period. Infants with ES also tend to develop atypical febrile seizures. After primary infection, HHV-6 commonly establishes latency in the central nervous system (CNS) and sometimes reactivates in the hippocampus, causing limbic encephalitis and temporal lobe epilepsy. These HHV-6-associated CNS diseases due to virus reactivation can occur in both immunocompromised and immunocompetent hosts. This article summarizes HHV-6-associated seizures during childhood.

Original languageEnglish
Pages (from-to)46-49
Number of pages4
Issue number2
Publication statusPublished - Oct 2005
Externally publishedYes


  • Encephalitis
  • Encephalopathy
  • Febrile seizure
  • Human herpes virus-6
  • Neonatal seizure
  • Seizure
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Infectious Diseases


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