Hierarchical periodic micro/nano-structures on nitinol and their influence on oriented endothelialization and anti-thrombosis

Kosuke Nozaki, Togo Shinonaga, Noriko Ebe, Naohiro Horiuchi, Miho Nakamura, Yusuke Tsutsumi, Takao Hanawa, Masahiro Tsukamoto, Kimihiro Yamashita, Akiko Nagai

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


Abstract The applications of hierarchical micro/nano-structures, which possess properties of two-scale roughness, have been studied in various fields. In this study, hierarchical periodic micro/nano-structures were fabricated on nitinol, an equiatomic Ni-Ti alloy, using a femtosecond laser for the surface modification of intravascular stents. By controlling the laser fluence, two types of surfaces were developed: periodic nano- and micro/nano-structures. Evaluation of water contact angles indicated that the nano-surface was hydrophilic and the micro/nano-surface was hydrophobic. Endothelial cells aligned along the nano-structures on both surfaces, whereas platelets failed to adhere to the micro/nano-surface. Decorrelation between the responses of the two cell types and the results of water contact angle analysis were a result of the pinning effect. This is the first study to show the applicability of hierarchical periodic micro/nano-structures for surface modification of nitinol.

Original languageEnglish
Article number5599
Pages (from-to)1-6
Number of pages6
JournalMaterials Science and Engineering C
Publication statusPublished - Jul 25 2015
Externally publishedYes


  • Cell orientation
  • Femtosecond laser
  • Hierarchical micro/nano-structures
  • Nitinol stents
  • Platelet adhesion

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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