High concentration of a gastrin releasing peptide-like immunoreactive substance in pregnant human milk

Masaharu Takeyama; Kazuhiro Kondo; Fusako Takayama; Rie Kondo; Hiroyuki Murata; Isao Miyakawa

doi:10.1016/S0006-291X(05)80275-X

High concentration of a gastrin releasing peptide-like immunoreactive substance in pregnant human milk

Masaharu Takeyama, Kazuhiro Kondo, Fusako Takayama, Rie Kondo, Hiroyuki Murata, Isao Miyakawa

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The level of a gastrin releasing peptide-like immunoreactive substance (GRP-IS) in human milk and plasma during late pregnancy and after delivery was measured. GRP-IS in milk increased during late pregnancy (1.3 nM at 39 weeks) and decreased after delivery (100 pM). GRP-IS in plasma during late pregnancy and after delivery was much lower (below 2 pM). By using HPLC and gel-filtration chromatography, two peaks of GRP-IS were purified. The one was coeluted with GRP(18-27) and the other was a prohormone. The GRP-IS in milk during pregnancy was mostly composed of proGRP. These results suggest that GRP may be produced and secreted in mammary glands.

Original language	English
Pages (from-to)	931-937
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	176
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(05)80275-X
Publication status	Published - Apr 30 1991
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/S0006-291X(05)80275-X

Cite this

@article{9a84451227f24ebfa5b0d7d08eeccaca,

title = "High concentration of a gastrin releasing peptide-like immunoreactive substance in pregnant human milk",

abstract = "The level of a gastrin releasing peptide-like immunoreactive substance (GRP-IS) in human milk and plasma during late pregnancy and after delivery was measured. GRP-IS in milk increased during late pregnancy (1.3 nM at 39 weeks) and decreased after delivery (100 pM). GRP-IS in plasma during late pregnancy and after delivery was much lower (below 2 pM). By using HPLC and gel-filtration chromatography, two peaks of GRP-IS were purified. The one was coeluted with GRP(18-27) and the other was a prohormone. The GRP-IS in milk during pregnancy was mostly composed of proGRP. These results suggest that GRP may be produced and secreted in mammary glands.",

author = "Masaharu Takeyama and Kazuhiro Kondo and Fusako Takayama and Rie Kondo and Hiroyuki Murata and Isao Miyakawa",

year = "1991",

month = apr,

day = "30",

doi = "10.1016/S0006-291X(05)80275-X",

language = "English",

volume = "176",

pages = "931--937",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - High concentration of a gastrin releasing peptide-like immunoreactive substance in pregnant human milk

AU - Takeyama, Masaharu

AU - Kondo, Kazuhiro

AU - Takayama, Fusako

AU - Kondo, Rie

AU - Murata, Hiroyuki

AU - Miyakawa, Isao

PY - 1991/4/30

Y1 - 1991/4/30

N2 - The level of a gastrin releasing peptide-like immunoreactive substance (GRP-IS) in human milk and plasma during late pregnancy and after delivery was measured. GRP-IS in milk increased during late pregnancy (1.3 nM at 39 weeks) and decreased after delivery (100 pM). GRP-IS in plasma during late pregnancy and after delivery was much lower (below 2 pM). By using HPLC and gel-filtration chromatography, two peaks of GRP-IS were purified. The one was coeluted with GRP(18-27) and the other was a prohormone. The GRP-IS in milk during pregnancy was mostly composed of proGRP. These results suggest that GRP may be produced and secreted in mammary glands.

AB - The level of a gastrin releasing peptide-like immunoreactive substance (GRP-IS) in human milk and plasma during late pregnancy and after delivery was measured. GRP-IS in milk increased during late pregnancy (1.3 nM at 39 weeks) and decreased after delivery (100 pM). GRP-IS in plasma during late pregnancy and after delivery was much lower (below 2 pM). By using HPLC and gel-filtration chromatography, two peaks of GRP-IS were purified. The one was coeluted with GRP(18-27) and the other was a prohormone. The GRP-IS in milk during pregnancy was mostly composed of proGRP. These results suggest that GRP may be produced and secreted in mammary glands.

UR - http://www.scopus.com/inward/record.url?scp=0025755636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025755636&partnerID=8YFLogxK

U2 - 10.1016/S0006-291X(05)80275-X

DO - 10.1016/S0006-291X(05)80275-X

M3 - Article

C2 - 2025302

AN - SCOPUS:0025755636

SN - 0006-291X

VL - 176

SP - 931

EP - 937

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

High concentration of a gastrin releasing peptide-like immunoreactive substance in pregnant human milk

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this