High-dose etoposide treatment for CNS involvement in a patient with primary non-Hodgkin's lymphoma of the breast

Hiroyuki Kohara; Hiroshi Ueoka; Masahiro Tabata; Katsuji Shinagawa; Kyoichi Hayashi; Mine Harada

doi:10.2169/internalmedicine.36.738

High-dose etoposide treatment for CNS involvement in a patient with primary non-Hodgkin's lymphoma of the breast

Hiroyuki Kohara, Hiroshi Ueoka, Masahiro Tabata, Katsuji Shinagawa, Kyoichi Hayashi, Mine Harada

University Hospital

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A 46-year-old man was referred to us for treatment of non-Hodgkin's lymphoma (NHL; diffuse large immunoblastic B cell type), which had initially developed in the breast. He was treated with five courses of chemotherapy with CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) and achieved a complete response. One year later, he noticed a gait disturbance. Magnetic resonance imaging (MRI) of the brain showed multiple nodules. A few abnormal cells were found in the cerebrospinal fluid (CSF). He was treated with high-dose etoposide (1,350 mg/m²/course). After two courses, both the multiple nodular lesions in the brain and the abnormal cells in the CSF were resolved. High-dose etoposide is effective for CNS involvement by NHL.

Original language	English
Pages (from-to)	738-741
Number of pages	4
Journal	Internal Medicine
Volume	36
Issue number	10
DOIs	https://doi.org/10.2169/internalmedicine.36.738
Publication status	Published - 1997

Keywords

Breast lymphoma
Central nervous system (CNS) lymphoma
High-dose etoposide

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.36.738

Cite this

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abstract = "A 46-year-old man was referred to us for treatment of non-Hodgkin's lymphoma (NHL; diffuse large immunoblastic B cell type), which had initially developed in the breast. He was treated with five courses of chemotherapy with CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) and achieved a complete response. One year later, he noticed a gait disturbance. Magnetic resonance imaging (MRI) of the brain showed multiple nodules. A few abnormal cells were found in the cerebrospinal fluid (CSF). He was treated with high-dose etoposide (1,350 mg/m2/course). After two courses, both the multiple nodular lesions in the brain and the abnormal cells in the CSF were resolved. High-dose etoposide is effective for CNS involvement by NHL.",

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AU - Kohara, Hiroyuki

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AU - Tabata, Masahiro

AU - Shinagawa, Katsuji

AU - Hayashi, Kyoichi

AU - Harada, Mine

PY - 1997

Y1 - 1997

N2 - A 46-year-old man was referred to us for treatment of non-Hodgkin's lymphoma (NHL; diffuse large immunoblastic B cell type), which had initially developed in the breast. He was treated with five courses of chemotherapy with CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) and achieved a complete response. One year later, he noticed a gait disturbance. Magnetic resonance imaging (MRI) of the brain showed multiple nodules. A few abnormal cells were found in the cerebrospinal fluid (CSF). He was treated with high-dose etoposide (1,350 mg/m2/course). After two courses, both the multiple nodular lesions in the brain and the abnormal cells in the CSF were resolved. High-dose etoposide is effective for CNS involvement by NHL.

AB - A 46-year-old man was referred to us for treatment of non-Hodgkin's lymphoma (NHL; diffuse large immunoblastic B cell type), which had initially developed in the breast. He was treated with five courses of chemotherapy with CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) and achieved a complete response. One year later, he noticed a gait disturbance. Magnetic resonance imaging (MRI) of the brain showed multiple nodules. A few abnormal cells were found in the cerebrospinal fluid (CSF). He was treated with high-dose etoposide (1,350 mg/m2/course). After two courses, both the multiple nodular lesions in the brain and the abnormal cells in the CSF were resolved. High-dose etoposide is effective for CNS involvement by NHL.

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KW - Central nervous system (CNS) lymphoma

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High-dose etoposide treatment for CNS involvement in a patient with primary non-Hodgkin's lymphoma of the breast

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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