@article{209535f371cf4bf5b93f3db8d6c868e2,
title = "High-throughput screening of bioactive compounds via new catalytic reaction in the pooled mixture",
abstract = "To increase the chances of finding new candidate molecules with medicinal properties, while expending less resource and effort, the present study used pooled substrates as starting materials. A bisindole compound that showed inhibitory activity was then isolated from the mixture, and the activity was improved by optimizing the substituents on the indole skeleton.",
keywords = "Bisindole, Brefeldin A, Golgi, High-throughput screening, Secretion",
author = "Ayano Satoh and Yuta Nishina",
note = "Funding Information: We thank Ryo Sakuma, Naoya Yuuki, Naoki Morimoto, Mayumi Oda, Toshiko Sunagawa, Takuya Nojima, and Hideyuki Suzuki (Okayama University) for their technical assistance. We are grateful to the technical staff of the Comprehensive Analysis Center of the Institute of Scientific and Industrial Research (Osaka University) for their assistance. This work was performed under the Cooperative Research Program of ?Network Joint Research Center for Materials and Devices.?, This research was supported by JSPS KAKENHI Grant Number 23570167, 26440055 and 18K06133 of MEXT (Ministry of Education, Sport, Culture, Science and Technology in Japan), and the Futaba Electronics Memorial Foundation for A.S. Funding Information: This research was supported by JSPS KAKENHI Grant Number 23570167 , 26440055 and 18K06133 of MEXT (Ministry of Education, Sport, Culture, Science and Technology in Japan), and the Futaba Electronics Memorial Foundation for A.S. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = oct,
day = "1",
doi = "10.1016/j.bmcl.2019.06.061",
language = "English",
volume = "29",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "19",
}