TY - JOUR
T1 - High-turnover osteopenia in preterm infants
T2 - Determination of urinary pyridinium cross-links of collagen
AU - Tsukahara, Hirokazu
AU - Takeuchi, Motohiro
AU - Fujisawa, Kazuo
AU - Miura, Masakazu
AU - Hata, Keishi
AU - Yamamoto, Kazutaka
AU - Mayumi, Mitsufumi
PY - 1998
Y1 - 1998
N2 - Osteopenia is a frequent condition in preterm infants, but its pathogenesis is uncertain. In the present study, we measured longitudinal changes in the excretion of pyridinium cross-links of collagen (specific markers of bone resorption) and evaluated the relationship between collagen cross-links and other indexes of bone and renal function in preterm infants. In these infants, urinary collagen cross-links were markedly increased on day 7 and day 30 of life and at estimated full-term gestation. The values were several times higher than those of older children and almost comparable to those of healthy full-term infants. Cross-link excretion did not correlate with β2-microglobulin (B2M) or N-acetyl-β-D-glucosaminidase (NAG) activity (markers of renal function), indicating that cross-link excretion is not influenced directly by infantile renal function. High serum osteocalcin and low bone mineral density (BMD) in the lumbar spine were also observed at estimated full-term gestation. There was no significant correlation between collagen cross-link excretion and either serum osteocalcin or spine BMD. We conclude that a state of high bone turnover underlies the development of osteopenia in preterm infants.
AB - Osteopenia is a frequent condition in preterm infants, but its pathogenesis is uncertain. In the present study, we measured longitudinal changes in the excretion of pyridinium cross-links of collagen (specific markers of bone resorption) and evaluated the relationship between collagen cross-links and other indexes of bone and renal function in preterm infants. In these infants, urinary collagen cross-links were markedly increased on day 7 and day 30 of life and at estimated full-term gestation. The values were several times higher than those of older children and almost comparable to those of healthy full-term infants. Cross-link excretion did not correlate with β2-microglobulin (B2M) or N-acetyl-β-D-glucosaminidase (NAG) activity (markers of renal function), indicating that cross-link excretion is not influenced directly by infantile renal function. High serum osteocalcin and low bone mineral density (BMD) in the lumbar spine were also observed at estimated full-term gestation. There was no significant correlation between collagen cross-link excretion and either serum osteocalcin or spine BMD. We conclude that a state of high bone turnover underlies the development of osteopenia in preterm infants.
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U2 - 10.1016/S0026-0495(98)90266-9
DO - 10.1016/S0026-0495(98)90266-9
M3 - Article
C2 - 9500572
AN - SCOPUS:0031911011
SN - 0026-0495
VL - 47
SP - 333
EP - 335
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 3
ER -
