Highly enantioselective and efficient synthesis of methyl (R)-o-chloromandelate with recombinant E. coli: Toward practical and green access to clopidogrel

Tadashi Ema; Nobuyasu Okita; Sayaka Ide; Takashi Sakai

doi:10.1039/b703463f

Highly enantioselective and efficient synthesis of methyl (R)-o-chloromandelate with recombinant E. coli: Toward practical and green access to clopidogrel

Tadashi Ema, Nobuyasu Okita, Sayaka Ide, Takashi Sakai

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Methyl (R)-o-chloromandelate ((R)-1), which is an intermediate for a platelet aggregation inhibitor named clopidogrel, was obtained in >99% ee by the asymmetric reduction of methyl o-chlorobenzoylformate (2) (up to 1.0 M) with recombinant E. coli overproducing a versatile carbonyl reductase.

Original language	English
Pages (from-to)	1175-1176
Number of pages	2
Journal	Organic and Biomolecular Chemistry
Volume	5
Issue number	8
DOIs	https://doi.org/10.1039/b703463f
Publication status	Published - Apr 12 2007

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "Methyl (R)-o-chloromandelate ((R)-1), which is an intermediate for a platelet aggregation inhibitor named clopidogrel, was obtained in >99% ee by the asymmetric reduction of methyl o-chlorobenzoylformate (2) (up to 1.0 M) with recombinant E. coli overproducing a versatile carbonyl reductase.",

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AU - Ide, Sayaka

AU - Sakai, Takashi

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AB - Methyl (R)-o-chloromandelate ((R)-1), which is an intermediate for a platelet aggregation inhibitor named clopidogrel, was obtained in >99% ee by the asymmetric reduction of methyl o-chlorobenzoylformate (2) (up to 1.0 M) with recombinant E. coli overproducing a versatile carbonyl reductase.

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Highly enantioselective and efficient synthesis of methyl (R)-o-chloromandelate with recombinant E. coli: Toward practical and green access to clopidogrel

Abstract

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