Abstract
Highly selective Friedel-Crafts monoalkylation, which was intrinsically difficult to be achieved by conventional methods, has been accomplished by micromixing. N-Acyliminium ion generated by the "cation pool" method was used as an alkylating agent and 1,3,5-trimethoxybenzene was used as an aromatic compound. The reaction in a macro-scale batch reactor (magnetic stirring) gave rise to the formation of a mixture of the monoalkylation product and the dialkylation product in ca. 1:1 ratio, but the use of a multilamination-type micromixer led to selective monoalkylation (92% yield). Based on the micromixing, the selective sequential dialkylation using two different alkylating agents was achieved.
| Original language | English |
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| Pages | 141-144 |
| Number of pages | 4 |
| Publication status | Published - Dec 1 2004 |
| Externally published | Yes |
| Event | Analytical, Mechanistic, and Synthetic Organic Electrochemistry - The Sixth International Manuel M. Baizer Symposium in Honor of Dennis H. Evans and Masao Tokuda - San Antonio, TX, United States Duration: May 9 2004 → May 14 2004 |
Other
| Other | Analytical, Mechanistic, and Synthetic Organic Electrochemistry - The Sixth International Manuel M. Baizer Symposium in Honor of Dennis H. Evans and Masao Tokuda |
|---|---|
| Country/Territory | United States |
| City | San Antonio, TX |
| Period | 5/9/04 → 5/14/04 |
ASJC Scopus subject areas
- Engineering(all)