Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons

Koreaki Sugimoto; Koji Abe; Tsong Hai Lee; Eiko Sakurai; Kazuhiko Yanai; Kyuya Kogure; Yasuto Itoyama; Takehiko Watanabe

doi:10.1016/0006-8993(94)90784-6

Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons

Koreaki Sugimoto, Koji Abe, Tsong Hai Lee, Eiko Sakurai, Kazuhiko Yanai, Kyuya Kogure, Yasuto Itoyama, Takehiko Watanabe

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The effect of (S)α-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.

Original language	English
Pages (from-to)	279-283
Number of pages	5
Journal	Brain Research
Volume	666
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)90784-6
Publication status	Published - Dec 15 1994
Externally published	Yes

Keywords

(S)α-Fluoromethylhistidine
CA2
Gerbil
Hippocampus
Histamine
Ischemia

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(94)90784-6

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title = "Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons",

abstract = "The effect of (S)α-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.",

keywords = "(S)α-Fluoromethylhistidine, CA2, Gerbil, Hippocampus, Histamine, Ischemia",

author = "Koreaki Sugimoto and Koji Abe and Lee, {Tsong Hai} and Eiko Sakurai and Kazuhiko Yanai and Kyuya Kogure and Yasuto Itoyama and Takehiko Watanabe",

note = "Funding Information: This work was partly supported by Grants-in-Aid for Scientific Research (c) 0680705, (b) 05454663 and 05557008 and a Grant-in-Aid for Scientific Research on Priority Areas (Kanazawa, I.) 06272204 from the Ministry of Education, Science and Culture of Japan and by a grant (Hirai, S.) from the Ministry for Health and Welfare of Japan.",

year = "1994",

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doi = "10.1016/0006-8993(94)90784-6",

language = "English",

volume = "666",

pages = "279--283",

journal = "Brain Research",

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T1 - Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons

AU - Sugimoto, Koreaki

AU - Abe, Koji

AU - Lee, Tsong Hai

AU - Sakurai, Eiko

AU - Yanai, Kazuhiko

AU - Kogure, Kyuya

AU - Itoyama, Yasuto

AU - Watanabe, Takehiko

N1 - Funding Information: This work was partly supported by Grants-in-Aid for Scientific Research (c) 0680705, (b) 05454663 and 05557008 and a Grant-in-Aid for Scientific Research on Priority Areas (Kanazawa, I.) 06272204 from the Ministry of Education, Science and Culture of Japan and by a grant (Hirai, S.) from the Ministry for Health and Welfare of Japan.

PY - 1994/12/15

Y1 - 1994/12/15

N2 - The effect of (S)α-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.

AB - The effect of (S)α-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.

KW - (S)α-Fluoromethylhistidine

KW - CA2

KW - Gerbil

KW - Hippocampus

KW - Histamine

KW - Ischemia

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SN - 0006-8993

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JO - Brain Research

JF - Brain Research

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ER -

Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons

Abstract

Keywords

ASJC Scopus subject areas

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