Histamine H3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice

Maria Alejandra Hossen, Yoko Fujii, Yukio Sugimoto, Ryoji Kayasuga, Chiaki Kamei

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The participation of histamine H3 receptors in the regulation of skin vascular permeability changes in mast cell-deficient mice was studied. Although intradermal injection of histamine H3 antagonists, iodophenpropit and clobenpropit, at a dose of 100 nmol/site caused significant increases in skin vascular permeability in both mast cell-deficient (WBB6F1 W/Wv) and wild-type (WBB6F1 +/+) mice, this response was significantly lower in mast cell-deficient mice than in the wild-type controls. Histamine also caused dose-related increases in skin vascular permeability in both wild-type and mast cell-deficient mice. Significant effects were observed at doses of 10 and 100 nmol/site, and no significant difference in skin vascular permeability was observed between mast cell-deficient and wild-type mice. However, histamine contents of dorsal skin in mast cell-deficient mice were significantly lower than in wild-type mice. In addition, the H1 antagonists diphenhydramine and chlorpheniramine and the NK1 antagonists, L-732,138 and L-733,060, were able to antagonize H3 antagonist-induced skin vascular permeability. These results indicated that blockade of H3 receptors by H3 antagonists induce skin vascular permeability through mast cell-dependent mechanisms. In addition, histamine and, to a lesser extent substance P are involved in the reaction.

Original languageEnglish
Pages (from-to)1563-1568
Number of pages6
JournalInternational Immunopharmacology
Issue number12
Publication statusPublished - Nov 2003


  • H agonists
  • H antagonists
  • Histamine
  • Vascular permeability

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology


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