Histamine Turnover in the Rat Hypothalamic Nuclei Estimated from α-Fluoromethylhistidine-lnduced Histamine Decrease

Yoshinori Itoh; Ryozo Oishi; Masahiro Nishibori; Kiyomi Saeki

doi:10.1254/jjp.51.581

Histamine Turnover in the Rat Hypothalamic Nuclei Estimated from α-Fluoromethylhistidine-lnduced Histamine Decrease

Yoshinori Itoh, Ryozo Oishi, Masahiro Nishibori, Kiyomi Saeki

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The turnover rates, rate constants and half-life values of neuronal histamine (HA) in 10 nuclei of the rat hypothalamus were estimated from the depletion of HA induced by α-fluoromethylhistidine (α-FMH: 100 mg/kg, i.p.), a specific inhibitor of histidine decarboxylase, on the presumption that α-FMH depletable HA pools represent neuronal ones. Marked variation in the HA turnover rates were observed among the hypothalamic nuclei, ranging from 5.7 to 19.5 pmo!e/mg protein/hr.

Original language	English
Pages (from-to)	581-584
Number of pages	4
Journal	the japanese journal of pharmacology
Volume	51
Issue number	4
DOIs	https://doi.org/10.1254/jjp.51.581
Publication status	Published - Mar 28 1988

ASJC Scopus subject areas

Pharmacology

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abstract = "The turnover rates, rate constants and half-life values of neuronal histamine (HA) in 10 nuclei of the rat hypothalamus were estimated from the depletion of HA induced by α-fluoromethylhistidine (α-FMH: 100 mg/kg, i.p.), a specific inhibitor of histidine decarboxylase, on the presumption that α-FMH depletable HA pools represent neuronal ones. Marked variation in the HA turnover rates were observed among the hypothalamic nuclei, ranging from 5.7 to 19.5 pmo!e/mg protein/hr.",

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AU - Saeki, Kiyomi

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AB - The turnover rates, rate constants and half-life values of neuronal histamine (HA) in 10 nuclei of the rat hypothalamus were estimated from the depletion of HA induced by α-fluoromethylhistidine (α-FMH: 100 mg/kg, i.p.), a specific inhibitor of histidine decarboxylase, on the presumption that α-FMH depletable HA pools represent neuronal ones. Marked variation in the HA turnover rates were observed among the hypothalamic nuclei, ranging from 5.7 to 19.5 pmo!e/mg protein/hr.

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Histamine Turnover in the Rat Hypothalamic Nuclei Estimated from α-Fluoromethylhistidine-lnduced Histamine Decrease

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