Histidine-rich glycoprotein modulates the blood-vascular system in septic condition

Hidenori Wake

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalActa medica Okayama
Issue number5
Publication statusPublished - 2019


  • Htidine-rich glycoprotein
  • Immunothrombosis
  • Septic pathogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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