TY - JOUR
T1 - Histidine-rich glycoprotein modulates the blood-vascular system in septic condition
AU - Wake, Hidenori
N1 - Funding Information:
This work was supported by grant from the Japan Agency for Medical Research and Development, AMED (18lk0201085h0001). We would like to thank Editage (www.editage.jp) for English language editing.
Publisher Copyright:
© 2019 by Okayama University Medical School.
PY - 2019
Y1 - 2019
N2 - Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis.
AB - Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis.
KW - Htidine-rich glycoprotein
KW - Immunothrombosis
KW - Septic pathogenesis
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M3 - Article
C2 - 31649362
AN - SCOPUS:85074088580
SN - 0386-300X
VL - 73
SP - 379
EP - 382
JO - Acta Medica Okayama
JF - Acta Medica Okayama
IS - 5
ER -