Histologic evaluation of human alveolar sockets treated with an artificial bone substitute material

Mari Wakimoto, Takaaki Ueno, Azumi Hirata, Seiji Iida, Tara Aghaloo, Peter K. Moy

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


This study involved a histologic, enzyme histologic, immunohistologic, and three-dimensional microstructure evaluating the extent of osteogenesis and repair in the human alveolar extraction socket achievable with an artificial bone substitute. After tooth extraction in 7 patients, extraction sockets were filled with Mastergraft (15% hydroxyapatite, 85% β-tricalcium phosphate complex). Radiomicrographs and histologic examinations were performed on samples obtained during dental implant placement procedure. On micro-computed tomography, new bone was observed in all collected samples, and osteogenesis was observed to have taken place around the artificial bone substitute. Histologically, active osteogenesis was found throughout the region observed. Addition of new bone around the Mastergraft was observed, and osteoblast-like cells were present. Cells that had partially invaded the artificial bone included tartrate-resistant acid phosphate-positive and CD34-positive cells. These findings indicate that the Mastergraft artificial bone induced osteogenesis in the jawbone and seemed effective for repairing bone defects.

Original languageEnglish
Pages (from-to)490-493
Number of pages4
JournalJournal of Craniofacial Surgery
Issue number2
Publication statusPublished - Mar 2011


  • human alveolar socket repair
  • hydroxyapatite
  • osteoblast
  • osteoclast
  • β-Tricalcium phosphate

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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