Histological and Nuclear Medical Comparison of Inflammation after Hemostasis with Non-Thermal Plasma and Thermal Coagulation

Masashi Ueda; Daiki Yamagami; Keiko Watanabe; Asami Mori; Hiroyuki Kimura; Kohei Sano; Hideo Saji; Kenji Ishikawa; Masaru Hori; Hajime Sakakita; Yuzuru Ikehara; Shuichi Enomoto

doi:10.1002/ppap.201500099

Histological and Nuclear Medical Comparison of Inflammation after Hemostasis with Non-Thermal Plasma and Thermal Coagulation

Masashi Ueda, Daiki Yamagami, Keiko Watanabe, Asami Mori, Hiroyuki Kimura, Kohei Sano, Hideo Saji, Kenji Ishikawa, Masaru Hori, Hajime Sakakita, Yuzuru Ikehara, Shuichi Enomoto

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The objective of this study is to examine the invasiveness of hemostasis by non-thermal plasma (NTP) compared with hemostasis by thermal coagulation (TC). The inflammation recovery process after hemostasis by TC and NTP was compared by using histological methods and nuclear medical molecular imaging. The necrotic areas in the NTP group disappeared after 5 days, whereas they remained 15 days after hemostasis in the TC group. The accumulation of 2-deoxy-2-[¹⁸F]fluoro-d-glucopyranose (¹⁸F-FDG), which reflects the existence of inflammatory cells, was higher in the TC group than in the NTP group on day 15. Thus, this study indicates that hemostasis by NTP is less inflammatory than TC. This report is the first to evaluate inflammation that occurred after hemostasis with medical devices noninvasively.

Original language	English
Pages (from-to)	1338-1342
Number of pages	5
Journal	Plasma Processes and Polymers
Volume	12
Issue number	12
DOIs	https://doi.org/10.1002/ppap.201500099
Publication status	Published - Dec 1 2015

Keywords

hemostasis
imaging
inflammation
non-thermal plasma
positron emission tomography

ASJC Scopus subject areas

Condensed Matter Physics
Polymers and Plastics

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title = "Histological and Nuclear Medical Comparison of Inflammation after Hemostasis with Non-Thermal Plasma and Thermal Coagulation",

abstract = "The objective of this study is to examine the invasiveness of hemostasis by non-thermal plasma (NTP) compared with hemostasis by thermal coagulation (TC). The inflammation recovery process after hemostasis by TC and NTP was compared by using histological methods and nuclear medical molecular imaging. The necrotic areas in the NTP group disappeared after 5 days, whereas they remained 15 days after hemostasis in the TC group. The accumulation of 2-deoxy-2-[18F]fluoro-d-glucopyranose (18F-FDG), which reflects the existence of inflammatory cells, was higher in the TC group than in the NTP group on day 15. Thus, this study indicates that hemostasis by NTP is less inflammatory than TC. This report is the first to evaluate inflammation that occurred after hemostasis with medical devices noninvasively.",

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author = "Masashi Ueda and Daiki Yamagami and Keiko Watanabe and Asami Mori and Hiroyuki Kimura and Kohei Sano and Hideo Saji and Kenji Ishikawa and Masaru Hori and Hajime Sakakita and Yuzuru Ikehara and Shuichi Enomoto",

note = "Funding Information: The authors are grateful to Okayama Medical Inovation Center for their assistance with image analyses. This study was supported in part by a Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Plasma Medical Innovation (KAKENHI no. 25108508 and 15H00895) from the Japan Society for the Promotion of Science. Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

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AU - Ueda, Masashi

AU - Yamagami, Daiki

AU - Watanabe, Keiko

AU - Mori, Asami

AU - Kimura, Hiroyuki

AU - Sano, Kohei

AU - Saji, Hideo

AU - Ishikawa, Kenji

AU - Hori, Masaru

AU - Sakakita, Hajime

AU - Ikehara, Yuzuru

AU - Enomoto, Shuichi

N1 - Funding Information: The authors are grateful to Okayama Medical Inovation Center for their assistance with image analyses. This study was supported in part by a Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Plasma Medical Innovation (KAKENHI no. 25108508 and 15H00895) from the Japan Society for the Promotion of Science. Publisher Copyright: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The objective of this study is to examine the invasiveness of hemostasis by non-thermal plasma (NTP) compared with hemostasis by thermal coagulation (TC). The inflammation recovery process after hemostasis by TC and NTP was compared by using histological methods and nuclear medical molecular imaging. The necrotic areas in the NTP group disappeared after 5 days, whereas they remained 15 days after hemostasis in the TC group. The accumulation of 2-deoxy-2-[18F]fluoro-d-glucopyranose (18F-FDG), which reflects the existence of inflammatory cells, was higher in the TC group than in the NTP group on day 15. Thus, this study indicates that hemostasis by NTP is less inflammatory than TC. This report is the first to evaluate inflammation that occurred after hemostasis with medical devices noninvasively.

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Histological and Nuclear Medical Comparison of Inflammation after Hemostasis with Non-Thermal Plasma and Thermal Coagulation

Abstract

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