Histopathological safety evaluation of newly-developed MgO sealer

K. Nakano, M. Tomida, M. Sato, S. Matsuura, A. Yamamoto, E. Kasahara, Toshiyuki Kawakami

Research output: Contribution to journalArticlepeer-review


We aimed to evaluate the subcutaneous tissue reaction to a newly-developed MgO Sealer for root canals. We injected the experimental material and three existing control materials into the dorsal area of 43 male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding sites was removed and histopathological examination was performed. The results demonstrate that the basic histopathological reaction is the formation of fibrous capsules consisting of granulation tissue around the experimental and control embedded materials. Based on our results, we believe that the newly-developed MgO Sealer is as safe as the existing control materials and can be considered for dental use as a root canal sealer.

Original languageEnglish
Pages (from-to)526-530
Number of pages5
JournalEuropean journal of medical research
Issue number12
Publication statusPublished - Dec 2 2011
Externally publishedYes


  • Histopathological evaluation
  • Magnesium oxide
  • Root canal sealer
  • Tissue reaction

ASJC Scopus subject areas

  • Medicine(all)


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