TY - JOUR
T1 - Homeobox transcription factor engrailed homeobox 1 is a possible diagnostic marker for adenoid cystic carcinoma and polymorphous adenocarcinoma
AU - Baba, Shunichi
AU - Akashi, Takumi
AU - Kayamori, Kou
AU - Ohuchi, Tomoyuki
AU - Ogawa, Ikuko
AU - Kubota, Nobuhisa
AU - Nakano, Keisuke
AU - Nagatsuka, Hitoshi
AU - Hasegawa, Hiromasa
AU - Matsuzaka, Kenichi
AU - Tomii, Shohei
AU - Uchida, Keisuke
AU - Katsuta, Noriko
AU - Sekiya, Takahiro
AU - Ando, Noboru
AU - Miura, Keiko
AU - Ishibashi, Hironori
AU - Ariizumi, Yousuke
AU - Asakage, Takahiro
AU - Michi, Yasuyuki
AU - Harada, Hiroyuki
AU - Sakamoto, Kei
AU - Eishi, Yoshinobu
AU - Okubo, Kenichi
AU - Ikeda, Tohru
N1 - Funding Information:
The authors thank Masaki Sekine, Haruka Yanagida, Yuri Itakura, Miwako Hamagaki and Morito Kurata for their technical assistance, Kaoru Kusama, Kentaro Kikuchi and Kousuke Marutsuka for their database analysis.
Publisher Copyright:
© 2020 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd
PY - 2021/2
Y1 - 2021/2
N2 - Diagnostic utility of a homeobox transcription factor, engrailed homeobox 1 (En1) in the histopathology of salivary gland neoplasms was studied. The expression of En1 was immunohistochemically examined in 51 cases of adenoid cystic carcinoma (AdCC) and 143 cases of other salivary gland neoplasms. In all 51 AdCCs, En1 was expressed in 30–100% of tumor cells. In eight of nine polymorphous adenocarcinomas (PACs), En1 was expressed in 40–100% of tumor cells. Less than 5% of tumor cells expressed En1 in three of 12 epithelial–myoepithelial carcinomas, one of 17 basal cell adenomas (BCAs), and one of 34 pleomorphic adenomas (PAs). Among 55 other carcinoma cases, 1–30% of tumor cells expressed En1 in three salivary duct carcinomas (SDCs) ex PA. None of the myoepitheliomas and Warthin tumors expressed En1. When the cut-off value of the percentage of En1-expressing cells was set to 25%, all 51 AdCCs, eight of nine PACs and one SDC ex PA were En1-positive and the others were En1-negative. En1 is expressed consistently in AdCCs, frequently in PACs, but rarely in other salivary gland neoplasms. En1 is a possible diagnostic marker for AdCC and PAC in the histopathology of salivary gland neoplasms.
AB - Diagnostic utility of a homeobox transcription factor, engrailed homeobox 1 (En1) in the histopathology of salivary gland neoplasms was studied. The expression of En1 was immunohistochemically examined in 51 cases of adenoid cystic carcinoma (AdCC) and 143 cases of other salivary gland neoplasms. In all 51 AdCCs, En1 was expressed in 30–100% of tumor cells. In eight of nine polymorphous adenocarcinomas (PACs), En1 was expressed in 40–100% of tumor cells. Less than 5% of tumor cells expressed En1 in three of 12 epithelial–myoepithelial carcinomas, one of 17 basal cell adenomas (BCAs), and one of 34 pleomorphic adenomas (PAs). Among 55 other carcinoma cases, 1–30% of tumor cells expressed En1 in three salivary duct carcinomas (SDCs) ex PA. None of the myoepitheliomas and Warthin tumors expressed En1. When the cut-off value of the percentage of En1-expressing cells was set to 25%, all 51 AdCCs, eight of nine PACs and one SDC ex PA were En1-positive and the others were En1-negative. En1 is expressed consistently in AdCCs, frequently in PACs, but rarely in other salivary gland neoplasms. En1 is a possible diagnostic marker for AdCC and PAC in the histopathology of salivary gland neoplasms.
KW - adenoid cystic carcinoma
KW - engrailed homeobox 1
KW - polymorphous adenocarcinoma
KW - salivary gland tumor
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U2 - 10.1111/pin.13050
DO - 10.1111/pin.13050
M3 - Article
C2 - 33333616
AN - SCOPUS:85097591403
SN - 1320-5463
VL - 71
SP - 113
EP - 123
JO - Pathology International
JF - Pathology International
IS - 2
ER -