Hormonal characteristics of primary aldosteronism due to unilateral adrenal hyperplasia

F. Otsuka, F. Otsuka-Misunaga, S. Koyama, H. Yamanari, Toshio Ogura, T. Ohe, H. Makino

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18 Citations (Scopus)


A case of unilateral adrenocortical hyperplasia is presented. A 46-year-old woman with a 7-year history of hypertension and a 1-year-history of hypokalemia was diagnosed with primary aldosteronism. Computed tomography, magnetic resonance imaging, venous sampling and adosterol scintigraphy exhibited a functioning left adrenal mass. The plasma aldosterone concentration increased markedly when furosemide with upright posture and either captopril or adrenocorticotropin were administered. Plasma renin activity was suppressed below the detectable range. Aldosterone secretion displayed a circadian rhythm and was not suppressed by dexamethasone administration. The resected left adrenal mass was pathologically diagnosed as adrenocortical nodular hyperplasia. Unilateral adrenal hyperplasia involving the zona glomerulosa rarely has been reported, with varying and incompletely characterized hormonal characteristics. This case report and literature review suggest unilateral adrenal hyperplasia as a rare cause of hyperaldosteronism with characteristies intermediate between idiopathie hyperaldosteronism and aldosterone-producing adrenocortical adenoma, resembling the functional features of the adenoma more closely.

Original languageEnglish
Pages (from-to)531-536
Number of pages6
JournalJournal of endocrinological investigation
Issue number8
Publication statusPublished - Sept 1998


  • Hypertension
  • Hypokalemia
  • Primary aldosteronism
  • Unilateral adrenal hyperplasia

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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