How to study boron biodistribution in liver metastases from colorectal cancer

Laura Roveda; U. Prati; J. Bakeine; F. Trotta; P. Marotta; P. Valsecchi; A. Zonta; R. Nano; A. Facoetti; P. Chiari; S. Barni; T. Pinelli; S. Altieri; A. Braghieri; P. Bruschi; F. Fossati; P. Pedroni

doi:10.1080/1120009x.2004.11782375

How to study boron biodistribution in liver metastases from colorectal cancer

Laura Roveda, U. Prati, J. Bakeine, F. Trotta, P. Marotta, P. Valsecchi, A. Zonta, R. Nano, A. Facoetti, P. Chiari, S. Barni, T. Pinelli, S. Altieri, A. Braghieri, P. Bruschi, F. Fossati, P. Pedroni

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The purpose of this study was to evaluate boron distribution for a safe and effective BNCT (Boron Neutron Capture Therapy) of liver metastases. Samples both from healthy and tumour liver parenchyma were analysed, after i.v. boron administration, by: α particles counting under neutron irradiation; morphological analysis by standard haematoxylin-eosin staining; neutron autoradiography. Our method was unaffected by the cytological heterogeneity inside tumour nodules; it demonstrated selective boron distribution in tumour tissue and predicted estimated mean therapeutic doses in tumour and safety doses in healthy tissue. The time interval for efficient BNCT was 2 to 4 hours after i.v. boron administration.

Original language	English
Pages (from-to)	15-18
Number of pages	4
Journal	Journal of Chemotherapy
Volume	16
Issue number	SUPPL. 5
DOIs	https://doi.org/10.1080/1120009x.2004.11782375
Publication status	Published - Nov 2004
Externally published	Yes

Keywords

Boron neutron capture therapy
Liver metastasis

ASJC Scopus subject areas

Oncology
Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/1120009x.2004.11782375

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Roveda, L., Prati, U., Bakeine, J., Trotta, F., Marotta, P., Valsecchi, P., Zonta, A., Nano, R., Facoetti, A., Chiari, P., Barni, S., Pinelli, T., Altieri, S., Braghieri, A., Bruschi, P., Fossati, F., & Pedroni, P. (2004). How to study boron biodistribution in liver metastases from colorectal cancer. Journal of Chemotherapy, 16(SUPPL. 5), 15-18. https://doi.org/10.1080/1120009x.2004.11782375

Roveda, L, Prati, U, Bakeine, J, Trotta, F, Marotta, P, Valsecchi, P, Zonta, A, Nano, R, Facoetti, A, Chiari, P, Barni, S, Pinelli, T, Altieri, S, Braghieri, A, Bruschi, P, Fossati, F & Pedroni, P 2004, 'How to study boron biodistribution in liver metastases from colorectal cancer', Journal of Chemotherapy, vol. 16, no. SUPPL. 5, pp. 15-18. https://doi.org/10.1080/1120009x.2004.11782375

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AU - Roveda, Laura

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AU - Bakeine, J.

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AU - Marotta, P.

AU - Valsecchi, P.

AU - Zonta, A.

AU - Nano, R.

AU - Facoetti, A.

AU - Chiari, P.

AU - Barni, S.

AU - Pinelli, T.

AU - Altieri, S.

AU - Braghieri, A.

AU - Bruschi, P.

AU - Fossati, F.

AU - Pedroni, P.

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How to study boron biodistribution in liver metastases from colorectal cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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