Human α-and β-defensin immunoreactivity in oral mucoepidermoid carcinomas

N. Mizukawa, K. Sawaki, H. Nagatsuka, M. Kamio, E. Yamachika, J. Fukunaga, T. Ueno, S. Takagi, T. Sugahara

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


The purpose of this study was to demonstrate the immunohistochemical localization and distribution of human α-and β-defensins, peptides with antimicrobial activity, in oral mucoepidermoid carcinoma tissue. Tissue samples were embedded in paraffin and α- and β-defensins were immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells that constituted the ducts, as well as neutrophils, were positively immunostained with the anti-α-defensin antibody (HNPs). On the other hand, epidermoid cells and intermediate cells were intensely stained with the anti-β-defensin-2 (HBD-2) antibody. Mucous-secreting cells were clearly not immunostained with the anti-HBD-2 antibody. The epithelial hyperplasia region adjacent to the tumor tissues was also positively immunostained with the anti-HBD-2 antibody.

Original languageEnglish
Pages (from-to)2171-2174
Number of pages4
JournalAnticancer research
Issue number3 C
Publication statusPublished - 2001


  • Defensin
  • HBD-2
  • Mucoepidermoid carcinoma
  • β-defensin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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