Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains

Tomomi Takahashi; Hideki Nakagoshi; Akinori Sarai; Nobuo Nomura; Tadashi Yamamoto; Shunsuke Ishii

doi:10.1016/0014-5793(94)01402-M

Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains

Tomomi Takahashi, Hideki Nakagoshi, Akinori Sarai, Nobuo Nomura, Tadashi Yamamoto, Shunsuke Ishii

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

The myb gene family has three members, c-myb, A-myb, and B-myb. A-myb mRNA is mainly expressed in testis and peripheral blood leukocytes. A-Myb can activate transcription from the promoter containing Myb-binding sites in all cells examined. In addition to the two domains (a DNA-binding domain and a transcriptional activation domain), two negative regulatory domains have been identified in A-Myb. These results indicate that A-Myb functions as a transcriptional activator mainly in testis and peripheral blood cells, and the regulatory mechanism of A-Myb activity is similar to that of c-Myb.

Original language	English
Pages (from-to)	89-96
Number of pages	8
Journal	FEBS Letters
Volume	358
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(94)01402-M
Publication status	Published - Jan 16 1995
Externally published	Yes

Keywords

A-myb gene
Negative regulatory domain
Tissue-specific expression
Transcriptional activator

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(94)01402-M

Cite this

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title = "Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains",

abstract = "The myb gene family has three members, c-myb, A-myb, and B-myb. A-myb mRNA is mainly expressed in testis and peripheral blood leukocytes. A-Myb can activate transcription from the promoter containing Myb-binding sites in all cells examined. In addition to the two domains (a DNA-binding domain and a transcriptional activation domain), two negative regulatory domains have been identified in A-Myb. These results indicate that A-Myb functions as a transcriptional activator mainly in testis and peripheral blood cells, and the regulatory mechanism of A-Myb activity is similar to that of c-Myb.",

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T1 - Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains

AU - Takahashi, Tomomi

AU - Nakagoshi, Hideki

AU - Sarai, Akinori

AU - Nomura, Nobuo

AU - Yamamoto, Tadashi

AU - Ishii, Shunsuke

PY - 1995/1/16

Y1 - 1995/1/16

N2 - The myb gene family has three members, c-myb, A-myb, and B-myb. A-myb mRNA is mainly expressed in testis and peripheral blood leukocytes. A-Myb can activate transcription from the promoter containing Myb-binding sites in all cells examined. In addition to the two domains (a DNA-binding domain and a transcriptional activation domain), two negative regulatory domains have been identified in A-Myb. These results indicate that A-Myb functions as a transcriptional activator mainly in testis and peripheral blood cells, and the regulatory mechanism of A-Myb activity is similar to that of c-Myb.

AB - The myb gene family has three members, c-myb, A-myb, and B-myb. A-myb mRNA is mainly expressed in testis and peripheral blood leukocytes. A-Myb can activate transcription from the promoter containing Myb-binding sites in all cells examined. In addition to the two domains (a DNA-binding domain and a transcriptional activation domain), two negative regulatory domains have been identified in A-Myb. These results indicate that A-Myb functions as a transcriptional activator mainly in testis and peripheral blood cells, and the regulatory mechanism of A-Myb activity is similar to that of c-Myb.

KW - A-myb gene

KW - Negative regulatory domain

KW - Tissue-specific expression

KW - Transcriptional activator

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Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains

Abstract

Keywords

ASJC Scopus subject areas

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