Human liver microsomal oxidation products of Δ8-tetrahydrocannabi-nol (THC) were isolated and identified by thin-layer chromatography, gas chromatography and gas chromatography-mass spectrometry. As the results, five monohydroxylated metabolites including 11-hydroxy-Δ8-THC, and 8β,9α-dihydroxyhexahydrocannabinol were identified as trimethyl-silyl derivatives. Isolation of the dihydroxylated metabolite suggests that epoxy metabolite(s) may be formed from A8-THC in humans.
|Number of pages||4|
|Journal||Chemical and Pharmaceutical Bulletin|
|Publication status||Published - Jan 1 1983|
- human liver microsomes
- identification of metabolite
ASJC Scopus subject areas
- Drug Discovery