Human papillomavirus as a risk factor for head and neck cancers - A case-control study

Shinji Nishioka, Kunihiro Fukushima, Kazunori Nishizaki, Mehmet Gunduz, Susumu Tominaga, Motoharu Fukazawa, Nobuya Monden, Shuichi Watanabe, Yu Masuda, Hajime Ogura

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


A retrospective, case-control study was conducted to examine the relationship between the presence of human papillomavirus types 16 and 18 (HPV16/18) DNA and the risk of head and neck cancers. Twelve out of 74 (16.2%) head and neck cancers contained HPV16/18 DNA, while 3 out of 70 (4.2%) non-cancer controls showed HPV16/18 positivity by polymerase chain reaction. The presence of HPV16/18 DNA was associated with an increased risk of head and neck cancer formation, showing an odds ratio of 4.32, with a 95% confidence interval of 1.26-14.78. Although its epidemiological impact might be smaller than that of other factors like cigarette smoking, the presence of HPV16/18 DNA in the aerodigestive tract is suggested to be a risk factor for human head and neck cancers.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalActa Oto-Laryngologica, Supplement
Issue number540
Publication statusPublished - 1999
Externally publishedYes


  • Head and neck carcinomas
  • Human papillomavirus
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Otorhinolaryngology


Dive into the research topics of 'Human papillomavirus as a risk factor for head and neck cancers - A case-control study'. Together they form a unique fingerprint.

Cite this