Hydroamination of alkynes catalyzed by palladium/benzoic acid

Leopold Mpaka Lutete; Isao Kadota; Akinori Shibuya; Yoshinori Yamamoto

Hydroamination of alkynes catalyzed by palladium/benzoic acid

Leopold Mpaka Lutete, Isao Kadota, Akinori Shibuya, Yoshinori Yamamoto

Research output: Contribution to journal › Article › peer-review

Abstract

The reaction of internal alkynes (1) with amines (2) in the presence of catalytic amount of Pd(PPh₃)₄ and benzoic acid in dioxane at 100°C gave the allylic amines (3) in good to excellent yields. The intramolecular reaction of alkynes with tethered amino groups (4) gave 2-vinylpyrrolidines and 2-vinylpiperidines (5) in good to excellent yields.

Original language	English
Pages (from-to)	347-357
Number of pages	11
Journal	Heterocycles
Volume	58
Publication status	Published - Nov 22 2002
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

Cite this

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title = "Hydroamination of alkynes catalyzed by palladium/benzoic acid",

abstract = "The reaction of internal alkynes (1) with amines (2) in the presence of catalytic amount of Pd(PPh3)4 and benzoic acid in dioxane at 100°C gave the allylic amines (3) in good to excellent yields. The intramolecular reaction of alkynes with tethered amino groups (4) gave 2-vinylpyrrolidines and 2-vinylpiperidines (5) in good to excellent yields.",

author = "Lutete, {Leopold Mpaka} and Isao Kadota and Akinori Shibuya and Yoshinori Yamamoto",

year = "2002",

month = nov,

day = "22",

language = "English",

volume = "58",

pages = "347--357",

journal = "Heterocycles",

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publisher = "Japan Institute of Heterocyclic Chemistry",

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T1 - Hydroamination of alkynes catalyzed by palladium/benzoic acid

AU - Lutete, Leopold Mpaka

AU - Kadota, Isao

AU - Shibuya, Akinori

AU - Yamamoto, Yoshinori

PY - 2002/11/22

Y1 - 2002/11/22

N2 - The reaction of internal alkynes (1) with amines (2) in the presence of catalytic amount of Pd(PPh3)4 and benzoic acid in dioxane at 100°C gave the allylic amines (3) in good to excellent yields. The intramolecular reaction of alkynes with tethered amino groups (4) gave 2-vinylpyrrolidines and 2-vinylpiperidines (5) in good to excellent yields.

AB - The reaction of internal alkynes (1) with amines (2) in the presence of catalytic amount of Pd(PPh3)4 and benzoic acid in dioxane at 100°C gave the allylic amines (3) in good to excellent yields. The intramolecular reaction of alkynes with tethered amino groups (4) gave 2-vinylpyrrolidines and 2-vinylpiperidines (5) in good to excellent yields.

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M3 - Article

AN - SCOPUS:0037159792

SN - 0385-5414

VL - 58

SP - 347

EP - 357

JO - Heterocycles

JF - Heterocycles

ER -

Hydroamination of alkynes catalyzed by palladium/benzoic acid

Abstract

ASJC Scopus subject areas

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