Hydrogel-based biomimetic environment for in vitro cell and tissue manipulation

Research output: Chapter in Book/Report/Conference proceedingChapter


A biomimetic environment fabricated with synthetic material would be an effective tool for reproducing the tissue-developmental process and even for achieving tissue engineering in vitro. A hydrogel material is one candidate for this tool, because a hydrogel normally shows harmless properties in regard to cells and tissue, and it can be tuned chemically and physically to obtain the desired form. Accordingly, fibrin gel was utilized to reproduce the 3D cellular orientations found in muscle tissue, fabricate tendon-like mineralized tissue, and regulate vascular formation. In this context, cell and tissue manipulations within the gel were led by in vitro physical and chemical stimulations. In this chapter, the approach used for manipulating cells and tissues using the designed hydrogel is discussed.

Original languageEnglish
Title of host publicationInterface Oral Health Science 2014
Subtitle of host publicationInnovative Research on Biosis-Abiosis Intelligent Interface
PublisherSpringer Japan
Number of pages8
ISBN (Electronic)9784431551928
ISBN (Print)9784431551256
Publication statusPublished - Jan 1 2015


  • Biomimetic environment
  • Cell manipulation
  • Hydrogel
  • In vitro tissue engineering

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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