Hydroxyurea as an inhibitor of hepatitis C virus RNA replication

Akito Nozaki, Manabu Morimoto, Masaaki Kondo, Takashi Oshima, Kazushi Numata, Shin Fujisawa, Takeshi Kaneko, Eiji Miyajima, Satoshi Morita, Kyoko Mori, Masanori Ikeda, Nobuyuki Kato, Katsuaki Tanaka

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Hepatitis C virus (HCV) is the main causative agent of chronic liver disease, which may develop into liver cirrhosis and hepatocellular carcinoma. By using a recently developed reporter assay system in which genome-length HCV RNA replicates efficiently, we found that hydroxyurea (HU), a DNA synthesis inhibitor, inhibited HCV RNA replication. Moreover, we demonstrated that the anti-HCV activity of the combination of IFN-alpha and HU was higher than that of IFN-alpha alone. These results suggest that HU may be an effective anti-HCV reagent that can be used not only singly but also in combination with IFN-alpha to treat chronic hepatitis C.

Original languageEnglish
Pages (from-to)601-605
Number of pages5
JournalArchives of Virology
Issue number4
Publication statusPublished - Apr 2010
Externally publishedYes

ASJC Scopus subject areas

  • Virology


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