Hyperleptinemia is associated with hypertension in Japanese males

Takuya Imatoh, Motonobu Miyazaki, Yoshito Momose, Yoko Uryu, Shinichi Tanihara, Hiroshi Une, Hiroyuki Doi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Leptin is a hormone which is predominantly secreted by adipose tissue. Recent studies have shown that leptin increases arterial blood pressure. Although data from available animal studies clearly indicate an association between leptin and hypertension, results of human studies have been less definitive. We conducted a case-control study to examine the association between serum leptin levels and hypertension in 111 hypertensive subjects and 222 male controls, using conditional logistic regression analyses. Mean serum leptin levels were found to be marginally higher in the case subjects than in the control subjects (3.3 ng/ml versus 3.0 ng/ml), however, conditional logistic regression analysis revealed that subjects in the highest quartile had a significantly increased risk of hypertension compared with those in the lowest quartile, even after adjusting for drinking status and diabetes mellitus (adjusted OR, 2.11; 95% CI, 1.01-4.39). Our findings suggest that leptin plays an important role in the development of hypertension. Copyright

Original languageEnglish
Article number4
JournalActa medica Okayama
Issue number3
Publication statusPublished - Jun 2008
Externally publishedYes


  • Epidemiological study
  • Hyperleptinemia
  • Hypertension
  • Leptin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Hyperleptinemia is associated with hypertension in Japanese males'. Together they form a unique fingerprint.

Cite this