Hypersensitivity pneumonitis caused by a home ultrasonic humidifier contaminated with Candida guilliermondii

Akemi Ando, Hideharu Hagiya, Takahiro Nada, Kosuke Kimura, Koichi Waseda, Kanmei Rai, Yoshihisa Hanayama, Fumio Otsuka

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


We herein report the first documented case of acute hypersensitivity pneumonitis in which Candida guilliermondii was the possible causative organism. A young Japanese woman presented to our hospital with relapsing respiratory symptoms accompanied by high fever. A detailed interview revealed that the onset of the symptoms occurred shortly after using a humidifier in her home. Her symptoms showed spontaneous improvement soon after admission, and an examination of her bronchoalveolar lavage fluid revealed the specific infiltration of inflammatory cells, which predominantly consisted of lymphocytes. Precipitin testing showed a positive reaction to C. guilliermondii, which was isolated from the home humidifier. Repeated history taking is essential for diagnosing occult respiratory disorders.

Original languageEnglish
Pages (from-to)3109-3112
Number of pages4
JournalInternal Medicine
Issue number22
Publication statusPublished - 2017


  • Candida guilliermondii
  • Hypersensitivity pneumonitis
  • Pleuritis
  • Recurrent pneumonia

ASJC Scopus subject areas

  • Internal Medicine


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