Hyrtinadines C and D, new azepinoindole-type alkaloids from a marine sponge Hyrtios sp.

Takaaki Kubota; Kenta Nakamura; Kanae Sakai; Jane Fromont; Tohru Gonoi; Jun'ichi Kobayashi

doi:10.1248/cpb.c16-00201

Hyrtinadines C and D, new azepinoindole-type alkaloids from a marine sponge Hyrtios sp.

Takaaki Kubota, Kenta Nakamura, Kanae Sakai, Jane Fromont, Tohru Gonoi, Jun'ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

New bisindole alkaloids, hyrtinadines C (1) and D (2), have been isolated from an Okinawan marine sponge Hyrtios sp. The structures of hyrtinadines C (1) and D (2) were elucidated based on analyses of the spectral data. Hyrtinadines C (1) and D (2) were the relatively rare alkaloids possessing a 3,4-fused azepinoindole skeleton. Hyrtinadines C (1) and D (2) showed antimicrobial activity.

Original language	English
Pages (from-to)	975-978
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	64
Issue number	7
DOIs	https://doi.org/10.1248/cpb.c16-00201
Publication status	Published - 2016
Externally published	Yes

Keywords

Antimicrobial activity
Azepinoindole
Bisindole
Hyrtinadine
Hyrtios sp.
Marine sponge

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1248/cpb.c16-00201

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title = "Hyrtinadines C and D, new azepinoindole-type alkaloids from a marine sponge Hyrtios sp.",

abstract = "New bisindole alkaloids, hyrtinadines C (1) and D (2), have been isolated from an Okinawan marine sponge Hyrtios sp. The structures of hyrtinadines C (1) and D (2) were elucidated based on analyses of the spectral data. Hyrtinadines C (1) and D (2) were the relatively rare alkaloids possessing a 3,4-fused azepinoindole skeleton. Hyrtinadines C (1) and D (2) showed antimicrobial activity.",

keywords = "Antimicrobial activity, Azepinoindole, Bisindole, Hyrtinadine, Hyrtios sp., Marine sponge",

author = "Takaaki Kubota and Kenta Nakamura and Kanae Sakai and Jane Fromont and Tohru Gonoi and Jun'ichi Kobayashi",

note = "Funding Information: We thank late Mr. Z. Nagahama and Mr. K. Uehara for his help with sponge collection, and Mr. K. Chiba, the Instrument Analysis Equipment Research Center, Showa Pharmaceutical University, for measurements of MS. This work was partially supported by JSPS KAKENHI Grant Number 25460115. Publisher Copyright: {\textcopyright} 2016 The Pharmaceutical Society of Japan.",

year = "2016",

doi = "10.1248/cpb.c16-00201",

language = "English",

volume = "64",

pages = "975--978",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "7",

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TY - JOUR

T1 - Hyrtinadines C and D, new azepinoindole-type alkaloids from a marine sponge Hyrtios sp.

AU - Kubota, Takaaki

AU - Nakamura, Kenta

AU - Sakai, Kanae

AU - Fromont, Jane

AU - Gonoi, Tohru

AU - Kobayashi, Jun'ichi

N1 - Funding Information: We thank late Mr. Z. Nagahama and Mr. K. Uehara for his help with sponge collection, and Mr. K. Chiba, the Instrument Analysis Equipment Research Center, Showa Pharmaceutical University, for measurements of MS. This work was partially supported by JSPS KAKENHI Grant Number 25460115. Publisher Copyright: © 2016 The Pharmaceutical Society of Japan.

PY - 2016

Y1 - 2016

N2 - New bisindole alkaloids, hyrtinadines C (1) and D (2), have been isolated from an Okinawan marine sponge Hyrtios sp. The structures of hyrtinadines C (1) and D (2) were elucidated based on analyses of the spectral data. Hyrtinadines C (1) and D (2) were the relatively rare alkaloids possessing a 3,4-fused azepinoindole skeleton. Hyrtinadines C (1) and D (2) showed antimicrobial activity.

AB - New bisindole alkaloids, hyrtinadines C (1) and D (2), have been isolated from an Okinawan marine sponge Hyrtios sp. The structures of hyrtinadines C (1) and D (2) were elucidated based on analyses of the spectral data. Hyrtinadines C (1) and D (2) were the relatively rare alkaloids possessing a 3,4-fused azepinoindole skeleton. Hyrtinadines C (1) and D (2) showed antimicrobial activity.

KW - Antimicrobial activity

KW - Azepinoindole

KW - Bisindole

KW - Hyrtinadine

KW - Hyrtios sp.

KW - Marine sponge

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DO - 10.1248/cpb.c16-00201

M3 - Article

C2 - 27373657

AN - SCOPUS:84978171053

SN - 0009-2363

VL - 64

SP - 975

EP - 978

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 7

ER -

Hyrtinadines C and D, new azepinoindole-type alkaloids from a marine sponge Hyrtios sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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