TY - JOUR
T1 - Identification and characterization of mouse SSX genes
T2 - A multigene family on the X chromosome with restricted cancer/testis expression
AU - Chen, Yao Tseng
AU - Alpen, Birgit
AU - Ono, Toshiro
AU - Gure, Ali O.
AU - Scanlan, Matthew A.
AU - Biggs, William H.
AU - Arden, Karen
AU - Nakayama, Eiichi
AU - Old, Lloyd J.
PY - 2003/12
Y1 - 2003/12
N2 - Human SSX was first identified as the gene involved in the t(X;18) translocation in synovial sarcoma. SSX is a multigene family, with 9 complete genes on chromosome Xp11. Normally expressed almost exclusively in testis, SSX mRNA is expressed in various human tumors, defining SSX as a cancer/testis antigen. We have now cloned the mouse ortholog of SSX. Mouse SSX genes can be divided into Ssxa and Ssxb subfamilies based on sequence homology. Ssxa has only one member, whereas 12 Ssxb genes, Ssxb1 to Ssxb12, were identified by cDNA cloning from mouse testis and mouse tumors. Both Ssxa and Ssxb are located on chromosome X and show tissue-restricted mRNA expression to testis among normal tissues. All putative human and mouse SSX proteins share conserved KRAB and SSX-RD domains. Mouse tumors were found to express some, but not all, Ssxb genes, similar to the SSX activation in human tumors.
AB - Human SSX was first identified as the gene involved in the t(X;18) translocation in synovial sarcoma. SSX is a multigene family, with 9 complete genes on chromosome Xp11. Normally expressed almost exclusively in testis, SSX mRNA is expressed in various human tumors, defining SSX as a cancer/testis antigen. We have now cloned the mouse ortholog of SSX. Mouse SSX genes can be divided into Ssxa and Ssxb subfamilies based on sequence homology. Ssxa has only one member, whereas 12 Ssxb genes, Ssxb1 to Ssxb12, were identified by cDNA cloning from mouse testis and mouse tumors. Both Ssxa and Ssxb are located on chromosome X and show tissue-restricted mRNA expression to testis among normal tissues. All putative human and mouse SSX proteins share conserved KRAB and SSX-RD domains. Mouse tumors were found to express some, but not all, Ssxb genes, similar to the SSX activation in human tumors.
KW - Cancer vaccine
KW - Cancer/testis antigens
KW - Tumor immunology
UR - http://www.scopus.com/inward/record.url?scp=0242678277&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242678277&partnerID=8YFLogxK
U2 - 10.1016/S0888-7543(03)00183-6
DO - 10.1016/S0888-7543(03)00183-6
M3 - Article
C2 - 14611804
AN - SCOPUS:0242678277
SN - 0888-7543
VL - 82
SP - 628
EP - 636
JO - Genomics
JF - Genomics
IS - 6
ER -
