TY - JOUR
T1 - Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen
AU - Peng, Lee F.
AU - Sun, Suk Kim
AU - Matchacheep, Sirinya
AU - Lei, Xiaoguang
AU - Su, Shun
AU - Lin, Wenyu
AU - Runguphan, Weerawat
AU - Choe, Won Hyeok
AU - Sakamoto, Naoya
AU - Ikeda, Masanori
AU - Kato, Nobuyuki
AU - Beeler, Aaron B.
AU - Porco, John A.
AU - Schreiber, Stuart L.
AU - Chung, Raymond T.
PY - 2007/10
Y1 - 2007/10
N2 - Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 μM). We then synthesized an analog of these compounds with optimized activity.
AB - Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 μM). We then synthesized an analog of these compounds with optimized activity.
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UR - http://www.scopus.com/inward/citedby.url?scp=34948838880&partnerID=8YFLogxK
U2 - 10.1128/AAC.00233-07
DO - 10.1128/AAC.00233-07
M3 - Article
C2 - 17682098
AN - SCOPUS:34948838880
SN - 0066-4804
VL - 51
SP - 3756
EP - 3759
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 10
ER -
