Identification of Pheophorbide a and Its Related Compounds as Possible Anti-tumor Promoters in the Leaves of Neptunia oleracea

Yoshimasa Nakamura; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi

doi:10.1271/bbb.60.1028

Identification of Pheophorbide a and Its Related Compounds as Possible Anti-tumor Promoters in the Leaves of Neptunia oleracea

Yoshimasa Nakamura, Akira Murakami, Koichi Koshimizu, Hajime Ohigashi

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Six chlorophyll-related compounds isolated from leaves of Neptunia oleracea (Leguminosae) inhibited the activation of tumor promoter-induced Epstein-Barr virus (EBV). Photo-irradiation of pheophorbide a, the major active constituent, did not enhance this inhibitory activity, and thus ruled out any photosensitizing effect playing the major role.

Original language	English
Pages (from-to)	1028-1030
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	60
Issue number	6
DOIs	https://doi.org/10.1271/bbb.60.1028
Publication status	Published - Jan 1996
Externally published	Yes

Keywords

Anti-tumor promoter
Chlorophylls
Epstein-Barr virus
Pheophorbides
Photocytotoxicity

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.60.1028

Cite this

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title = "Identification of Pheophorbide a and Its Related Compounds as Possible Anti-tumor Promoters in the Leaves of Neptunia oleracea",

abstract = "Six chlorophyll-related compounds isolated from leaves of Neptunia oleracea (Leguminosae) inhibited the activation of tumor promoter-induced Epstein-Barr virus (EBV). Photo-irradiation of pheophorbide a, the major active constituent, did not enhance this inhibitory activity, and thus ruled out any photosensitizing effect playing the major role.",

keywords = "Anti-tumor promoter, Chlorophylls, Epstein-Barr virus, Pheophorbides, Photocytotoxicity",

author = "Yoshimasa Nakamura and Akira Murakami and Koichi Koshimizu and Hajime Ohigashi",

note = "Funding Information: Acknowledglllents. This study was supported in part by a grant from the Ministry of Health and Welfare for the Second Term Comprehensive IO-Year Strategy for Cancer Control, Japan. We thank Dr. I. Sakata of Toyo-Hakka Co., Ltd. for kindly gift providing PPBa and the related compounds. We also thank Ms. S. Jiwajinda of Kasetsart University (Thailand) for collecting the plant samples.",

year = "1996",

month = jan,

doi = "10.1271/bbb.60.1028",

language = "English",

volume = "60",

pages = "1028--1030",

journal = "Bioscience, Biotechnology and Biochemistry",

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publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

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T1 - Identification of Pheophorbide a and Its Related Compounds as Possible Anti-tumor Promoters in the Leaves of Neptunia oleracea

AU - Nakamura, Yoshimasa

AU - Murakami, Akira

AU - Koshimizu, Koichi

AU - Ohigashi, Hajime

N1 - Funding Information: Acknowledglllents. This study was supported in part by a grant from the Ministry of Health and Welfare for the Second Term Comprehensive IO-Year Strategy for Cancer Control, Japan. We thank Dr. I. Sakata of Toyo-Hakka Co., Ltd. for kindly gift providing PPBa and the related compounds. We also thank Ms. S. Jiwajinda of Kasetsart University (Thailand) for collecting the plant samples.

PY - 1996/1

Y1 - 1996/1

N2 - Six chlorophyll-related compounds isolated from leaves of Neptunia oleracea (Leguminosae) inhibited the activation of tumor promoter-induced Epstein-Barr virus (EBV). Photo-irradiation of pheophorbide a, the major active constituent, did not enhance this inhibitory activity, and thus ruled out any photosensitizing effect playing the major role.

AB - Six chlorophyll-related compounds isolated from leaves of Neptunia oleracea (Leguminosae) inhibited the activation of tumor promoter-induced Epstein-Barr virus (EBV). Photo-irradiation of pheophorbide a, the major active constituent, did not enhance this inhibitory activity, and thus ruled out any photosensitizing effect playing the major role.

KW - Anti-tumor promoter

KW - Chlorophylls

KW - Epstein-Barr virus

KW - Pheophorbides

KW - Photocytotoxicity

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JO - Bioscience, Biotechnology and Biochemistry

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Identification of Pheophorbide a and Its Related Compounds as Possible Anti-tumor Promoters in the Leaves of Neptunia oleracea

Abstract

Keywords

ASJC Scopus subject areas

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