TY - JOUR
T1 - Identify LD blocks based on hierarchical spatial data
AU - Tomita, Makoto
AU - Hatsumichi, Masahiro
AU - Kurihara, Koji
N1 - Funding Information:
We wish to express our gratitude to Mr. F. Ishioka, on the calculation of numerical example for his help. The present study was supported by grants from Pache Research Subsidy I-A-2, Nanzan University (2007) and The Hori Information Science Promotion Foundation.
PY - 2008/1/10
Y1 - 2008/1/10
N2 - A domain where recombination does not occur often, yet maintained linkage disequilibrium exists on DNA sequence is known as a "haplotype block" or "LD block". Many methods are available to identify LD blocks using disequilibrium parameters, such as the well-known Gabriel's method, Zhu's method and so on. We considered that Echelon analysis can be applied to identify LD block, and report herein that LD blocks can be identified according to our new method applying Echelon analysis. The results of numerical examples are also provided.
AB - A domain where recombination does not occur often, yet maintained linkage disequilibrium exists on DNA sequence is known as a "haplotype block" or "LD block". Many methods are available to identify LD blocks using disequilibrium parameters, such as the well-known Gabriel's method, Zhu's method and so on. We considered that Echelon analysis can be applied to identify LD block, and report herein that LD blocks can be identified according to our new method applying Echelon analysis. The results of numerical examples are also provided.
KW - Echelon analysis
KW - Haplotype block
KW - LD block
KW - SNPs
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U2 - 10.1016/j.csda.2007.05.035
DO - 10.1016/j.csda.2007.05.035
M3 - Article
AN - SCOPUS:35748977636
SN - 0167-9473
VL - 52
SP - 1806
EP - 1820
JO - Computational Statistics and Data Analysis
JF - Computational Statistics and Data Analysis
IS - 4
ER -